Arturs Sperga, Armands Kazia and Janis Veliks
Org. Biomol. Chem., 2021,19, 2688-2691
DOI:
10.1039/D1OB00270H,
Paper
The synthesis of five-membered rings using fluoromethylene transfer chemistry is an attractive method for building fluorinated products of high value. This work demonstrates for the first time that one-fluorine-one-carbon modification of a substrate could be a viable strategy to access monofluorinated five-membered rings. The synthetic methodology was developed to access monofluorinated isoxazoline-N-oxides in one step starting from substituted 2-nitroacrylates using fluoromethylsulfonium reagents.