Selective alkylation of parallel G-quadruplex structure

Kazumitsu Onizuka; Erchissaran Ganbold; Yue Ma; Shogo Sasaki; Madoka E. Hazemi; Yutong Chen; Norihiro Sato; Mamiko Ozawa; Kazuo Nagasawa; Fumi Nagatsugi

doi:10.1039/D0OB02365E

Selective alkylation of parallel G-quadruplex structure†

Kazumitsu Onizuka,^ab Erchissaran Ganbold,^ab Yue Ma,^c Shogo Sasaki,^d Madoka E. Hazemi,^ab Yutong Chen,^ab Norihiro Sato,^ab Mamiko Ozawa,^a Kazuo Nagasawa

*^d and Fumi Nagatsugi

*^ab

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* Corresponding authors

^a Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan
E-mail: nagatugi@tohoku.ac.jp

^b Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan

^c Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho Koganei, Tokyo 184-8588, Japan

^d Department of Biotechnology and LifeScience, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho Koganei, Tokyo 184-8588, Japan
E-mail: knaga@cc.tuat.ac.jp

Abstract

The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).

This article is part of the themed collection: Chemical Biology in OBC

Organic & Biomolecular Chemistry

Selective alkylation of parallel G-quadruplex structure†

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