Synthesis of C3-sulfone substituted naphthols via rhodium(iii)-catalyzed annulation of sulfoxonium ylides with alkynylsulfones

Abstract

C–H activation of sulfoxonium ylides catalyzed by rhodium(III) with subsequent annulation by alkynylsulfones was accomplished. This methodology offers a step-economical approach for assembling C3-sulfone-substituted naphthols with a high level of regioselectivity that is complementary to previous protocols. The approach has an extensive substrate spectrum and broad functional group tolerance.