Asymmetric β,γ′-regioselective [4 + 3] and [4 + 2] annulations of α-vinylenals via cascade iminium ion-dienamine catalysis

Yang Gao a, Xue Song a, Ru-Jie Yan a, Wei Du a and Ying-Chun Chen *ab
aKey Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. E-mail: ycchen@scu.edu.cn
bCollege of Pharmacy, Third Military Medical University, Chongqing 400038, China

Received 10th October 2020 , Accepted 22nd October 2020

First published on 22nd October 2020


Abstract

Introduction of an α-vinyl group into enal substrates can prohibit the traditional [3 + 2] cycloaddition with N-2,2,2-trifluoroethyl isatin imines catalysed by a chiral secondary amine, but give β,γ′-regioselective [4 + 3] annulation products via cascade iminium ion-dienamine catalysis. A spectrum of CF3-containing spirooxindoles incorporating an azepane motif were constructed with good to excellent enantioselectivities. In addition, asymmetric [4 + 2] annulations between α-vinylenals and α,α-dicyanoalkenes were disclosed through a similar catalytic strategy, generally affording complex tricyclic frameworks with outstanding enantioselectivities.


The seven-membered N-heterocycles, as a type of medium-sized ring motif, are ubiquitous in natural products and bioactive compounds, as exemplified in Fig. 1.1 Thus, the construction of such architectures, especially in an asymmetric catalytic manner, has attracted much attention.2 The enantioselective [4 + 3] annulation reaction from readily available starting materials, particularly classic 1,3-dipoles or in situ formed zwitterionic species, represents one of the most straightforward strategies to access these N-heterocycles,3 but faces the challenging transannular interactions and entropic effects during the ring formation process.4 With the development of asymmetric catalysis, a diversity of enantioenriched seven-membered rings have been synthesized via the catalysis of transition metals,5 phosphines,6 N-heterocyclic carbenes,7 Brønsted acids,8 or even via cooperative catalysis;9 however, similar reactions catalysed by chiral amines have been rarely explored.
image file: d0ob02068k-f1.tif
Fig. 1 Bioactive molecules containing seven-membered N-heterocycles.

Actually, asymmetric [3 + 2] dipolar cycloaddition reactions between α,β-unsaturated carbonyl compounds and 1,3-dipoles via iminium ion activation have been well documented, usually in a concerted manner (Scheme 1a).10 Nevertheless, the related [4 + 3] annulation reaction could not be possible by employing dienals or dienones with an extended double bond as substrates due to the more favourable [3 + 2] pathway (Scheme 1b).11 With the continuing interest in developing asymmetric [4 + 3] annulation reactions to construct seven-membered N-heterocycles,9c,12 we designed enals 1 with an α-vinyl group,13 which could be activated as iminium ions I in the presence of amine catalysts. It was envisaged that the classical [3 + 2] cycloaddition with 1,3-diploes might be prevented by the α-substituent because of the formation of a sterically hindered quaternary centre; in contrast, the β,γ′-regioselective [4 + 3] annulation pathway would be accomplished via cascade iminium ion-dienamine catalysis,14 finally affording the expected seven-membered N-heterocycles, as proposed in Scheme 1c.


image file: d0ob02068k-s1.tif
Scheme 1 Amine-catalysed cycloaddition or annulation reaction of unsaturated carbonyl compounds with 1,3-dipoles.

Based on the above considerations, we explored the reactions between readily available α-vinylenal 1a and several types of 1,3-dipole substrates.15 Although most previously formed 1,3-dipoles generally showed inert reactivity, fortunately, N-2,2,2-trifluoroethylisatin imine 2a,16 which can easily isomerize to active azomethine ylide-type species, exhibited good reactivity with 1a in DCE at 60 °C, under the catalysis of chiral secondary amine catalyst C1 and benzoic acid A1. The desired β,γ′-regioselective [4 + 3] product 3a, proceeding in a stepwise Michael addition and Mannich reaction, was isolated in a good yield with exclusive diastereoselectivity and high enantioselectivity (Table 1, entry 1). It should be noted that the α,β-regioselective cycloadduct was not detected.17 Subsequently, more catalytic parameters were screened to improve the enantiocontrol. Using bulkier amines C2 and C3 resulted in a dramatic decrease of yield (entries 2 and 3), and amines C4–C6 derived from L-hydroxyproline provided better enantioselectivity (entries 4–6). Nevertheless, the assemblies of amine C4 and other acid additives generally delivered inferior results (entries 7–10). Performing the reaction at lower temperature afforded slightly increased data (entry 11), but poor conversion was observed at 40 °C (entry 12). A few solvents were evaluated but no better results were obtained (entries 13–16). Finally, we conducted the asymmetric reaction on a larger scale, and comparable data were obtained (entry 17).

Table 1 Screening studies of [4 + 3] annulation of enal 1a and isatin imine 2aa

image file: d0ob02068k-u1.tif

Entry C A Solvent Yieldb (%) eec (%)
a Unless noted otherwise, reactions were performed with enal 1a (0.12 mmol, 1.2 equiv.), isatin imine 2a (0.1 mmol, 1.0 equiv.), amine C (0.02 mmol, 20 mol%) and acid A (0.02 mmol, 20 mol%) in solvent (0.2 mL) at 60 °C for 24 h. b Yield of the isolated product. c Determined by HPLC analysis on a chiral stationary phase; dr >19[thin space (1/6-em)]:[thin space (1/6-em)]1 by 1H NMR analysis. d At 50 °C. e At 40 °C. f On a 1.0 mmol scale.
1 C1 A1 DCE 80 83
2 C2 A1 DCE 65 83
3 C3 A1 DCE 40 85
4 C4 A1 DCE 70 91
5 C5 A1 DCE 70 88
6 C6 A1 DCE 62 87
7 C4 A2 DCE 65 83
8 C4 A3 DCE 60 90
9 C4 A4 DCE 45 80
10 C4 A5 DCE 68 90
11 C4 A1 DCE 75 92
12e C4 A1 DCE <10
13d C4 A1 CHCl3 80 88
14d C4 A1 THF 60 84
15d C4 A1 Toluene 70 88
16d C4 A1 CH3CN 72 90
17d,f C4 A1 DCE 70 90


Consequently, we explored the substrate scope and limitations of this [4 + 3] annulation reaction. The results are summarised in Table 2. First, an array of α-vinylenals 1 with diverse β-aryl or heteroaryl groups were explored in the reactions with N-2,2,2-trifluoroethylisatin imine 2a. In general, high to excellent enantioselectivities were obtained for the tested reactions (Table 2, entries 2–8), whereas slightly reduced yields were isolated for the substrates with electron-withdrawing ones (entries 2 and 3). Unfortunately, the enals 1 with β-alkyl substituents showed poor reactivity.15 High yield and enantioselectivity were produced for an enal 1i bearing an α-styryl group (entry 9), but the desired annulation products were not formed by using enals 1 having a γ′-alkyl group.15 On the other hand, a wide range of N-2,2,2-trifluoroethylisatin imines 2 with either electron-withdrawing or electron-donating groups on the phenyl ring could be well tolerated in the reactions with enal 1a, and the corresponding products 3j−3p were delivered in moderate to good yields with good to excellent enantioselectivities. Furthermore, the isatin imine derivatives 2 with an N-MOM or N-Bn group were also compatible (entries 17 and 18).

Table 2 Substrate scope and limitations of [4 + 3] annulationsa

image file: d0ob02068k-u2.tif

Entry R1, R2 R3, R4 Yieldb (%) eec (%)
a Unless noted otherwise, reactions were performed with enal 1 (0.12 mmol, 1.2 equiv.), isatin imine 2 (0.1 mmol, 1.0 equiv.), amine C4 (0.02 mmol, 20 mol%) and acid A1 (0.02 mmol, 20 mol%) in DCE (0.2 mL) at 50 °C for 12–24 h. b Yield of the isolated product. c Determined by HPLC analysis on a chiral stationary phase; dr >19[thin space (1/6-em)]:[thin space (1/6-em)]1 by 1H NMR analysis. d The absolute configuration of enantiopure 3b was determined by X-ray analysis. The other products were assigned by analogy.
1 Ph, H H, Me 3a, 75 92
2 3-BrC6H4, H H, Me 3b, 65 87d
3 4-BrC6H4, H H, Me 3c, 60 88
4 4-MeC6H4, H H, Me 3d, 80 91
5 3-MeOC6H4, H H, Me 3e, 80 92
6 4-MeOC6H4, H H, Me 3f, 73 86
7 2-Naphthyl, H H, Me 3g, 82 96
8 2-Thienyl, H H, Me 3h, 80 88
9 Ph, Ph H, Me 3i, 90 92
10 Ph, H 5-MeO, Me 3j, 75 96
11 Ph, H 5-Me, Me 3k, 75 96
12 Ph, H 6-Cl, Me 3l, 68 94
13 Ph, H 7-F, Me 3m, 60 94
14 Ph, H 7-Cl, Me 3n, 60 94
15 Ph, H 7-Me, Me 3o, 75 80
16 Ph, H 7-MeO, Me 3p, 78 94
17 Ph, H H, Bn 3q, 78 93
18 Ph, H H, MOM 3r, 80 94


The application of α-vinylenals 1 as successful 4C partners via cascade iminium ion-dienamine catalysis inspired us to explore their potential in other types of annulation reactions. Actually, six-membered carbocyclic compounds are widespread in nature, which could be efficiently constructed via concerted or stepwise [4 + 2] reactions.18 Electron-deficient α,α-dicyanoalkenes have been applied as bifunctional vinylogous Michael donors and Michael acceptors in [4 + 2] annulations with α,β-unsaturated ketones via aminocatalysis.19 As a result, we investigated the reaction between enal 1a and α,α-dicyanoalkene 4a (Table 3, X = S). To our gratification, the expected [4 + 2] annulation proceeded smoothly in THF at ambient temperature, and product 5a was obtained in an excellent yield with an outstanding ee value under the catalysis of amine C2 and acid A4 (Table 3, entry 1).15 A range of α-vinyl enals 1 with diverse β-aryl groups could be well tolerated in the reactions with substrate 4a, and the corresponding tricyclic frameworks 5b−5k were constructed in moderate to high yields with excellent enantioselectivities (entries 2–11). Nevertheless, a significantly reduced ee value was obtained by using enal 1i (entry 12). In addition, α,α-dicyanoalkene 4b derived from chroman-4-one exhibited much lower reactivity, whereas the desired adduct 5m was furnished in remarkable enantiocontrol (entry 13).

Table 3 Substrate scope and limitations of [4 + 2] annulations of enals 1 and α,α-dicyanoalkenes 4a

image file: d0ob02068k-u3.tif

Entry X R1, R2 Yieldb (%) eec (%)
a Unless noted otherwise, reactions were performed with enal 1 (0.12 mmol, 1.2 equiv.), α,α-dicyanoalkene 4 (0.1 mmol, 1.0 equiv.), amine C3 (0.02 mmol, 20 mol%) and acid A4 (0.02 mmol, 20 mol%) in THF (0.2 mL) at rt for 12 h. b Yield of the isolated product. c Determined by HPLC analysis on a chiral stationary phase; dr >19[thin space (1/6-em)]:[thin space (1/6-em)]1 by 1H NMR analysis. d The absolute configuration of enantiopure 5g was determined by X-ray analysis. The other products were assigned by analogy.
1 S Ph, H 5a, 92 98
2 S 3-ClC6H4, H 5b, 75 94
3 S 4-ClC6H4, H 5c, 92 98
4 S 4-BrC6H4, H 5d, 86 96
5 S 4-NO2C6H4, H 5e, 65 92
6 S 4-MeC6H4, H 5f, 89 99
7 S 2-MeOC6H4, H 5g, 70 98d
8 S 3-MeOC6H4, H 5h, 90 97
9 S 4-MeOC6H4, H 5i, 90 96
10 S 2-Naphthyl, H 5j, 76 98
11 S 2-Thienyl, H 5k, 95 99
12 S Ph, Ph 5l, 70 55
13 O Ph, H 5m, 48 93


In addition, the remaining α,β-unsaturated aldehyde moiety of cycloadduct 3a could participate in a [3 + 3] annulation reaction with cyclohexane-1,3-dione 6,20 and the product 7 with higher molecular complexity was obtained in a high yield (Scheme 2).


image file: d0ob02068k-s2.tif
Scheme 2 Synthetic transformation of product 3a.

In summary, we designed α-vinyl α,β-unsaturated aldehydes, which could be applied as 4C synthons in β,γ′-regioselective [4 + 3] annulations with N-2,2,2-trifluoroethylisatin imines via cascade iminium ion-dienamine catalysis, rather than the traditional α,β-regioselective [3 + 2] dipolar cycloadditions. A series of spirooxindoles incorporating an azepane motif were efficiently constructed with good to excellent enantioselectivities. These α-vinylenals could be further utilised in [4 + 2] annulations with bifunctional α,α-dicyanoalkenes via the same catalytic strategy, affording highly enantioenriched tricyclic architectures. More results in regard to these synthons will be reported in the future.

Conflicts of interest

There are no conflicts to declare.

Acknowledgements

We gratefully acknowledge the financial support from the National Natural Science Foundation of China (no. 21772126 and 21961132004).

Notes and references

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Footnote

Electronic supplementary information (ESI) available: Experimental procedures, spectroscopic data for new compounds, NMR, HRMS spectra and HPLC chromatograms, and CIF files of enantiopure products 3b and 5g (CCDC 2036410 and 2036411). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d0ob02068k

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