Issue 34, 2021

Electrochemical aptasensors for the detection of hepatocellular carcinoma-related biomarkers

Abstract

Hepatocellular carcinoma (HCC), one of the most dangerous malignant tumors worldwide, poses a huge threat to human life. The development of a tangible method for the early diagnosis of this disease remains a major challenge. The ability to accurately detect HCC-related biomarkers is beneficial for the early diagnosis and successful treatment of HCC. As nucleic acid ligands, aptamers are single-stranded oligonucleotides obtained by in vitro screening with high affinity and specificity for binding targets. Electrochemical aptamer-based biosensors (aptasensors) have attracted much attention in detecting HCC-related biomarkers based on the specificity of aptamer–target recognition. In addition, electrochemical aptasensors have been extensively considered in biomarker detection due to their high stability, high sensitivity, cost-effectiveness, and simplicity of fabrication. This review aims to introduce some representative studies and summarize the latest developments in the field of electrochemical aptasensors for the detection of HCC-related biomarkers in HCC diagnosis, including HCC cells, proteins, cell-derived exosomes, and nucleic acid. The current challenges and promising opportunities in the establishment of electrochemical aptasensors for HCC-related biomarker detection are also discussed.

Graphical abstract: Electrochemical aptasensors for the detection of hepatocellular carcinoma-related biomarkers

Article information

Article type
Perspective
Submitted
04 Mar 2021
Accepted
29 Jun 2021
First published
02 Jul 2021

New J. Chem., 2021,45, 15158-15169

Electrochemical aptasensors for the detection of hepatocellular carcinoma-related biomarkers

X. Shi, L. Chen, S. Chen and D. Sun, New J. Chem., 2021, 45, 15158 DOI: 10.1039/D1NJ01042E

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