Issue 30, 2021
From the journal:

Dalton Transactions

GSH-resistant and highly cytoselective ruthenium(ii)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents†

Binoy Kar,a   Utpal Das,a   Sourav De, ORCID logo a   Sudhindra Pete, ORCID logo a   Ajay Sharma S,a   Nilmadhab Roy,a   Ashok Kumar S. K.,a   Debashis Panda ORCID logo b  and  Priyankar Paira ORCID logo *a  

* Corresponding authors

a Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India
E-mail: priyankar.paira@vit.ac.in
Fax: +91-416-2243092
Tel: +91-416-2243091

b Department of Basic Sciences and Humanities, Rajiv Gandhi Institute of Petroleum Technology, An Institution of National Importance, Jais, Amethi-229304, Uttar Pradesh, India
E-mail: dpanda@rgipt.ac.in

Abstract

To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(II)-arene complexes. In this regard, luminescent ruthenium(II)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells.

Graphical abstract: GSH-resistant and highly cytoselective ruthenium(ii)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

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Article information

DOI
https://doi.org/10.1039/D1DT01604K
Article type
Communication
Submitted
18 May 2021
Accepted
12 Jul 2021
First published
12 Jul 2021

Dalton Trans., 2021,50, 10369-10373

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GSH-resistant and highly cytoselective ruthenium(II)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

B. Kar, U. Das, S. De, S. Pete, A. Sharma S, N. Roy, A. K. S. K., D. Panda and P. Paira, Dalton Trans., 2021, 50, 10369 DOI: 10.1039/D1DT01604K

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