Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO3˙−) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.
B. Halliwell, A. Adhikary, M. Dingfelder and M. Dizdaroglu, Chem. Soc. Rev., 2021, 50, 8355 DOI: 10.1039/D1CS00044F
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