Issue 71, 2021
From the journal:

Chemical Communications

A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue†

Vinayak Juvekar,‡a   Myoung Ki Cho,‡a   Hyo Won Lee,‡a   Dong Joon Lee,a   Hyuk Kang, ORCID logo a   Ju Man Song,b   Jong Tae Je*b  and  Hwan Myung Kim ORCID logo *a  

* Corresponding authors

a Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, South Korea
E-mail: kimhm@ajou.ac.kr

b Giheung R&D Center, SFC Co., Ltd, Yongin, South Korea
E-mail: jtje@sfc-dye.com

Abstract

A cyclocyanine (CC)-based organic small molecule two-photon (TP) fluorescent probe (CCNa1) was developed for mitochondrial sodium ion sensing. CCNa1 exhibits a low solvatochromic shift and strong TP fluorescence enhancement at 575 nm upon binding to Na+ and is insensitive to other metal ions and to pH. CCNa1 demonstrated fast cell loading ability, biocompatibility, and sensitive response to mitochondrial Na+ influx in live cells and mouse brain tissue.

Graphical abstract: A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue

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Article information

DOI
https://doi.org/10.1039/D1CC03617C
Article type
Communication
Submitted
06 Jul 2021
Accepted
10 Aug 2021
First published
10 Aug 2021

Chem. Commun., 2021,57, 8929-8932

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A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue

V. Juvekar, M. K. Cho, H. W. Lee, D. J. Lee, H. Kang, J. M. Song, J. T. Je and H. M. Kim, Chem. Commun., 2021, 57, 8929 DOI: 10.1039/D1CC03617C

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