Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging

Ke Zhang; Xiayun Le; Qiaoqin Yu; Juan Zhang; Dandan Wang; Tingting Chen; Xia Chu

doi:10.1039/D1CC02577E

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Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging†

Ke Zhang,^a Xiayun Le,^a Qiaoqin Yu,^b Juan Zhang,^a Dandan Wang,^a Tingting Chen

*^a and Xia Chu

*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Changsha, China

^b Hunan University, College of Chemistry and Chemical Engineering, Changsha, Hunan, China

Abstract

In this work, we have implemented a polymerase and endonuclease synergetic amplification reaction in living cells for intracellular miRNA imaging by using biomineralized ZIF-8 NPs.

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Article information

DOI: https://doi.org/10.1039/D1CC02577E
Article type: Communication
Submitted: 17 May 2021
Accepted: 27 Jul 2021
First published: 27 Jul 2021

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Chem. Commun., 2021,57, 8472-8475

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Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging

K. Zhang, X. Le, Q. Yu, J. Zhang, D. Wang, T. Chen and X. Chu, Chem. Commun., 2021, 57, 8472 DOI: 10.1039/D1CC02577E

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Chemical Communications

Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging†

Abstract

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Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging

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