Issue 37, 2021
From the journal:

Chemical Communications

Programming cell communications with pH-responsive DNA nanodevices†

Junjun Hou,ab   Shitai Zhu,ab   Ziwei Zhao,c   Jianlei Shen, ORCID logo d   Jie Chao,c   Jiye Shi,a   Jiang Li,e   Lihua Wang, ORCID logo ae   Zhilei Ge ORCID logo *d  and  Qian Li ORCID logo *d  

* Corresponding authors

a Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

b University of Chinese Academy of Sciences, Beijing, China

c Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, China

d School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, China
E-mail: gezhilei@sjtu.edu.cn, liqian2018@sjtu.edu.cn

e The Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China

Abstract

DNA nanoswitches on cell surfaces could respond to changes of pH under physiological conditions by switching from a three-chain structure to a double-chain structure, thus connecting another set of cells modified with complementary single-stranded DNA. This pH-triggered cell communication offers a promising approach for cell-based therapy under a tumor microenvironment.

Graphical abstract: Programming cell communications with pH-responsive DNA nanodevices

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Article information

DOI
https://doi.org/10.1039/D1CC00875G
Article type
Communication
Submitted
16 Feb 2021
Accepted
29 Mar 2021
First published
30 Mar 2021

Chem. Commun., 2021,57, 4536-4539

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Programming cell communications with pH-responsive DNA nanodevices

J. Hou, S. Zhu, Z. Zhao, J. Shen, J. Chao, J. Shi, J. Li, L. Wang, Z. Ge and Q. Li, Chem. Commun., 2021, 57, 4536 DOI: 10.1039/D1CC00875G

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