Issue 19, 2021

One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction

Abstract

In an effort designed to discover superior inhibitors of cyclophilin D (CypD), we identified and screened members of a one-bead-one-compound (OBOC) library of cyclic peptoid analogues of cyclosporin A (CsA). The results show that the one member of this cyclic peptoid family, I11, inhibits mitochondrial membrane potential changes mediated by CypD.

Graphical abstract: One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction

Supplementary files

Article information

Article type
Communication
Submitted
20 Dec 2020
Accepted
15 Jan 2021
First published
28 Jan 2021

Chem. Commun., 2021,57, 2388-2391

One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction

S. Hyun, N. Park, S. H. Nam, D. H. Cheon, Y. Lee, H. Lim and J. Yu, Chem. Commun., 2021, 57, 2388 DOI: 10.1039/D0CC08268F

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