Issue 23, 2021

A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

Abstract

A continuous flow process to generate [1.1.1]propellane on demand is presented rendering solutions of [1.1.1]propellane that can directly be derivatised into various bicyclo[1.1.1]pentane (BCP) species. This was realised in throughputs up to 8.5 mmol h−1 providing an attractive and straightforward access to gram quantities of selected BCP building blocks. Lastly, a continuous photochemical transformation of [1.1.1]propellane into valuable BCPs bearing mixed ester/acyl chloride moieties was developed.

Graphical abstract: A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

Supplementary files

Article information

Article type
Communication
Submitted
15 Dec 2020
Accepted
09 Feb 2021
First published
16 Feb 2021

Chem. Commun., 2021,57, 2871-2874

A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

K. Donnelly and M. Baumann, Chem. Commun., 2021, 57, 2871 DOI: 10.1039/D0CC08124H

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