Issue 21, 2021

The liquid micro junction-surface sampling probe (LMJ-SSP); a versatile ambient mass spectrometry interface

Abstract

Ambient ionization methods have become important tools in mass spectrometry. The LMJ-SSP can significantly simplify/reduce lengthy sample preparation requirements associated with mass spectrometry analysis. Samples may be introduced through direct contact, insertion and droplet injection, enabling applications from drug discovery and surface analysis to tissue profiling and metabolic mapping. This review examines the underlying principles associated with the LMJ-SSP interface and highlights modifications of the original design that have extended its capability. We summarize different application areas that have exploited the method and describe potential future directions for the adaptable ambient ionization source.

Graphical abstract: The liquid micro junction-surface sampling probe (LMJ-SSP); a versatile ambient mass spectrometry interface

Article information

Article type
Critical Review
Submitted
26 Apr 2021
Accepted
30 Aug 2021
First published
08 Sep 2021

Analyst, 2021,146, 6365-6378

The liquid micro junction-surface sampling probe (LMJ-SSP); a versatile ambient mass spectrometry interface

D. Simon and R. Oleschuk, Analyst, 2021, 146, 6365 DOI: 10.1039/D1AN00725D

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