Issue 19, 2024

Efficient reductive amination of 5-hydroxymethylfurfural by iridium-catalysed transfer hydrogenation

Abstract

Transfer hydrogenative reductive amination of 5-(hydroxymethy)furfural (HMF) has been accomplished, catalysed by a cyclometalated iridium catalyst with formic acid as a hydrogen source. The catalytic system afforded a TON of 9600 and TOF of 14 400 h−1, and the reaction can be successfully scaled up to a 10 gram scale at a substrate-to-catalyst ratio of 10 000. A wide range of amines could be coupled with HMF to afford furan derived products, including modified drug molecules, key intermediates for drug synthesis and potential monomers for polymer synthesis.

Graphical abstract: Efficient reductive amination of 5-hydroxymethylfurfural by iridium-catalysed transfer hydrogenation

Supplementary files

Article information

Article type
Paper
Submitted
29 Jun 2024
Accepted
05 Aug 2024
First published
10 Aug 2024

Catal. Sci. Technol., 2024,14, 5764-5769

Efficient reductive amination of 5-hydroxymethylfurfural by iridium-catalysed transfer hydrogenation

H. Liu, W. Tang, D. Xue, J. Xiao and C. Wang, Catal. Sci. Technol., 2024, 14, 5764 DOI: 10.1039/D4CY00812J

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