Chemoselective hydrogenation of heteroarenes and arenes by Pd–Ru–PVP under mild conditions

Abstract

Monometallic (Pd, Ru or Rh) and bimetallic (Pd_0.5–Ru_0.5) alloy NPs catalysts were examined for the hydrogenation of quinoline. Pd–Ru alloy catalyst showed superior catalytic activity to the traditional Rh catalyst. The characterization of Pd_0.5–Ru_0.5 catalysts, HAADF-EDX mapping and XPS analysis suggested that the alloy state of PdRu catalysts remained unchanged in the recovered catalyst. Furthermore, the catalyst was highly selective for the hydrogenation of different arenes.

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1,2,3,4-Tetrahydroquinolines are important building blocks for the synthesis of fine chemicals, pharmaceuticals and petrochemicals.^1–3 Traditionally, 1,2,3,4-tetrahydroquinolines have been synthesized by catalytic cyclization or the Beckman rearrangement method.^3–6 Direct hydrogenation of readily available quinoline by molecular hydrogen is a simple and atom-economical route for the hydrogenated quinoline compounds. Nevertheless, the hydrogenation of quinolines reaction suffers from catalyst deactivation caused by the strong interaction between the nitrogen atom of quinoline and active sites of the catalyst. Recently, several heterogeneous (Co, Au, Ru, Pt, Pd and Rh) catalysts have been developed to overcome the catalyst deactivation problem (Table S1†).^7–24 Specifically, Rh catalysts exhibits remarkably excellent activity in comparison with other noble metal catalysts but some of them require high temperature (>80 °C)^13,21 and/or high pressure (>10 bar).^14–21 Later, Rh/AlOOH and Rh nanoparticles (NPs) catalysts have been reported for efficient hydrogenation of quinolines under ambient conditions (1 bar H₂ and 25 °C).^22–24 Although high selectivity and activity of Rh catalysts, the high cost of Rh make it unfavourable for the industrial purposes. From the economical and environmental point of view, the cost-effective catalyst is necessary for the hydrogenation of quinolines under mild condition.

Solid-solution alloy method is a promising way for the synthesis of alloy NPs which offers an opportunity to control the electronic state of alloy by changing the composition ratio and/or different combinations of alloy in this method. In search of a cheap alternative for Rh catalyst, Pd and Ru are important metals because both metals are relatively cheaper than Rh metal and their well-known activity for hydrogenation reactions. We believe that Pd_0.5–Ru_0.5 solid solution alloy NPs could be alternative for the traditional Rh catalyst. However, a solid-solution alloy of Pd and Ru is a challenging task due to the immiscibility of Pd and Ru in bulk state.^25,26 Recently, our research group led by H. Kitagawa has reported the first successful example of Pd_0.5–Ru_0.5 NPs via a chemical reduction method using a nano-size effect which showed almost similar catalytic activity than those of Rh for CO oxidation and automobile exhaust purification.^27,28 As part of our continuing interest in the applications of Pd–Ru as pseudo Rh catalyst, we herein report that chemoselective hydrogenation of heteroarenes and arenes under mild condition.

In preliminary experiments, we carried out the hydrogenation of quinoline to 1,2,3,4-tetrahydroquinoline as model reaction (Table 1). Monometallic Pd and Ru catalysts were inactive for hydrogenation of quinoline (entries 1 and 2). In previous reports, our group has shown that the electronic state and consequently, catalytic activity of monometallic Pd and Ru could be modified by making Pd_0.5–Ru_0.5 alloy catalyst.^27,28 We found the similar trend using Pd_0.5Ru_0.5 catalyst and it showed full conversion with 95% yield of 1,2,3,4-tetrahydroquinolines (entry 3). The effect of the solvent showed that the reactivity of Pd_0.5Ru_0.5 was improved using methanol as solvent. Probably, methanol provides the better dispersion of Pd_0.5–Ru_0.5 NPs in the reactions and/or high solubility of hydrogen gas in methanol. Next, we examined the activity of previously reported Rh catalyst. Although, the particle size of Rh and Pd_0.5–Ru_0.5 was similar, the moderate yield of tetrahydroquinoline was obtained in the presence of Rh–PVP (entry 7). Due to the high amount of PVP, the catalytic activity of Rh was slightly declined via less interaction between quinoline and metal sites.²⁹

Table 1 Optimization of reaction conditions for hydrogenation of quinoline^a

Entry	Catalyst	Particle size^b (nm)	Conv. (%)	GC yield (%)
a Reaction conditions: quinoline (1 mmol), catalyst (2 mol%), CH3OH (1 mL), 5 bar H2, 25 °C, 6 h, CH3OH.b Determined by STEM analysis.c THF.d Toluene.e 1,4-Dioxane.f Ref. 38.
1	Ru–PVP	8.4 ± 2.4	13	13
2	Pd–PVP	4.8 ± 0.8	41	32
3	Pd0.5Ru0.5–PVP	5.6 ± 1.6	99	95
4^c	Pd0.5Ru0.5–PVP	5.6 ± 1.6	63	60
5^d	Pd0.5Ru0.5–PVP	5.6 ± 1.6	45	40
6^e	Pd0.5Ru0.5–PVP	5.6 ± 1.6	21	13
7	Rh–PVP	5.4 ± 1.0^f	66	66

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The substrate scope of Pd_0.5–Ru_0.5PVP catalyst was explored under mild reaction conditions (5 bar H₂ and 25 °C). As summarized in Table 2, quinolines with different functional groups converted to corresponding tetrahydroquinolines. The catalyst showed reduction of the heteroarene ring only. Pd_0.5–Ru_0.5 was also active for the hydrogenation of biologically important heterocyclic compounds such as 1,8-naphthyridine and quinazoline. O-Containing heterocycle, benzofuran was also transformed to 1,2-dihydrobenzofuran with high yield (80%).

Table 2 Hydrogenation of heteroarenes by Pd_0.5Ru_0.5PVP catalyst^a

Entry	Heteroarene	Product	Conv. (%)	GC yield (%)
a Reaction conditions: substrate (1 mmol), catalyst (2 mol%), 5 bar H2, 25 °C, 24 h.b 3,4-Dihydroquinazoline was obtained.
1			99	96
2			98	90
3			99	92
4			64	60
5			99	76
6			99	99
7			94	45^b
8			99	80

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Hydrogenation of arenes to saturated compounds is an important transformation for petrochemical and pharmaceutical industries. For instance, hydrogenation of benzoic acid to cyclohexanecarboxylic acid, it is used for the synthesis of pharmaceutical drugs such as ansatrienin.³⁰ Hydrogenation of benzoic acid has been reported by using supported and polymer stabilized metal nanoparticles.^31–38 Among them, Rh catalyst demonstrated the excellent activity for the hydrogenation of benzoic acid. The scope of Pd_0.5–R_0.5 catalyst was examined for different arene hydrogenation for the hydrogenation of benzoic acid. The scope of Pd_0.5–R_0.5 catalyst was examined for different arene hydrogenation under solvent-free condition (Table 3). Pd_0.5–Ru_0.5–PVP catalyst was able to hydrogenate benzoic acid with high yield. In previous reports, the role of solvent was explained for the selective hydrogenation of benzoic acid. The selectivity for cyclohexanecarboxylic acid was controlled using polar solvent (water). The byproduct (benzyl alcohol) was obtained using less polar solvent (cyclohexane). On the other hand, Pd_0.5–Ru_0.5–PVP catalyst showed the high activity in solvent-free conditions. Hydrogenation of benzene and its derivative were also studied under optimized conditions. The high yields of the corresponding hydrogenated products was obtained in the presence of the Pd_0.5–Ru_0.5 catalyst.

Table 3 Hydrogenation of arenes by Pd_0.5Ru_0.5PVP catalyst^a

Entry	Arene	Product		Conv. (%)	GC yield (%)
a Reaction conditions: substrate (1 mmol), catalyst (2 mol%), 10 bar H2, 150 °C, 24 h.
1			99		94
2			99		92
3			99		99
4			95		95
5			99		92
6			80		60

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The reusability of Pd_0.5–Ru_0.5 catalyst was investigated using optimized condition (5 bar H₂ and 25 °C) for the hydrogenation of quinoline. The catalyst was washed by acetone multiple times after completion of reaction and separated by centrifugation. The recovered catalyst was dried under vacuum at 40 °C for 12 h and reused without further purification. The catalyst was reused three times without loss in activity (Fig. 1).

Fig. 1 Recycle experiment for the hydrogenation of quinoline over Pd_0.5Ru_0.5–PVP catalyst.

To study morphological changes, the fresh and recovered catalyst after the 1st cycle was analysed by high-angle annular dark field. The reconstructed overlaying image of fresh Pd_0.5–Ru_0.5 catalyst revealed that Pd and Ru atom was distributed equally in the particle which indicated the formation of Pd_0.5Ru_0.5 alloy via homogeneous mixing at atomic-level. Dealloying and/or aggregation were not observed in Pd_0.5–Ru_0.5 (Fig. 2). Next, the electronic state of fresh and used Pd_0.5–Ru_0.5 catalyst was examined by XPS (Fig. 3). In our previous reports, the binding energy of Pd_0.5–Ru_0.5 was shifted positively in 3d_5/2 (334.5 eV) from 3d_5/2 (334.30 eV) of monontellic Pd and negatively in 3P_3/2 (460.6 eV) from 3P_3/2 (461.4 eV) of monometallic Ru.³⁹ Such shifting was also observed in fresh and used Pd_0.5–Ru_0.5 catalyst. From these results, we concluded that the electronic state of used catalysts was not changed significantly after 1st cycle.

Fig. 2 HAADF-STEM images Pd-L and Ru-L STEM-EDX maps and reconstructed overlay images of fresh (A) and recovered (B) Pd_0.5–Ru_0.5–PVP catalyst.

Fig. 3 XPS spectra for Pd_0.5–Ru_0.5̲fresh (blue) and Pd_0.5–Ru_0.5̲used (red) with Pd 3d (A) and Ru 3p (B).

The superiority of Pd_0.5–Ru_0.5 alloy over Pd and Ru can be explained by unique electronic state. Our group has used first-principles methods to study the electronic states of Pd, Ru, Rh, and the Pd_0.5–Ru_0.5 alloy. Interestingly, we have found that the electronic state of the Pd–Ru alloy differs from those of the parental Pd or Ru metal. This result has indicated that a new electronic state is produce by alloying Pd and Ru. The density of state of the Pd_0.5–Ru_0.5 alloy is similar to that of Rh.

Furthermore, Pd_0.5–Ru_0.5 alloy shows the electron transfer from Pd to Ru and produced the partial positive (δ+) charge at Pd and partial negative charge (δ−) at Ru. This unique electronic state with bifunctional sites of Pd_0.5–Ru_0.5 alloy made it favorable for chemoselective for hydrogenation of quinoline. In case of monometallic Pd or Ru catalyst, the strong adsorption of quinoline might be responsible for low conversion of quinoline.

It is well-known that the hydrogenation of organic functional group such as C=C and C=N proceeded via heterolytic cleavage of H₂. Such cleavage of H₂ yielded to H⁺ and H⁻ using metal and support/ligand.^8,37 In colloidal Pd_0.5Ru_0.5 catalyst, the heterolytic cleavage of hydrogen proceeded using bifunctional sites of Pd_0.5–Ru_0.5 catalysis (Scheme 1). The better H₂ cleavage over bifunctional sites of Pd_0.5Ru_0.5 catalyst may have been responsible for the higher catalytic activity of the Pd_0.5–Ru_0.5 catalyst for the hydrogenation of quinoline.

Scheme 1 Plausible transition state for the hydrogenation of quinoline by Pd_0.5–Ru_0.5–PVP.

In summary, we have developed a successful example of Pd_0.5–Ru_0.5 NPs for the hydrogenation of N-,O-heteroarenes and arenes. This catalyst exhibited the higher activity than Rh catalyst which was extensively studied for the hydrogenation of quinoline. A parametric study demonstrated that methanol was the best solvent for the hydrogenation of heteroarenes, whereas solvent-free conditions facilitated for the hydrogenation of arenes. The catalyst was recycled three times recycled without loss in activity. It is likely that Pd_0.5–Ru_0.5 NPs could be efficient catalysts for the hydrogenation of nitroarenes and synthesis of N-heterocycles. Currently, we are exploring this possibility.

Author contributions

Chandan Chaudhari: designing of research, data collection, analysis and writing-editing. Katsutoshi Sato: data curation and validation. Yoshihide Nishida: data collection. Katsutoshi Nagaoka: designing of research, data collection, analysis and writing-editing. Yasuyuki Ikeda, Kenji Terada and Naoya Abe: catalyst preparation. Tomokazu Yamamoto, Takaaki Toriyama and Syo Matsumura: HAADF-STEM analysis. Kohei Kusuda and Hiroshi Kitagawa: XPS analysis and catalyst design.

Conflicts of interest

There are no conflicts to declare.

Acknowledgements

This research was supported by the ACCEL program, Japan Science and Technology Agency (JST), JPMJAC1501.

Notes and references

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Footnote

† Electronic supplementary information (ESI) available. See DOI: 10.1039/d0ra09981c

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