Jennifer M. Schomaker
| Professor Schomaker began her research career as a college freshman at Dow Chemical in Organic Chemicals and Polymers, later moving to a full-time position in Agricultural Chemicals Process Research, where she participated in route selection and scale-up campaigns for two new herbicides. During her employment, she completed her B.S. and M.S. degrees in Chemistry, then left Dow to attend graduate school at Michigan State University, where she obtained her Ph.D. in 2006 with Prof. Babak Borhan. She then moved to UC-Berkeley as an NIH postdoctoral fellow with Prof. Robert G. Bergman and F. Dean Toste. Since 2009, she has been Professor of Chemistry at the University of Wisconsin-Madison. Her awards include the NSF-CAREER, Sloan Research Fellowship, Thieme Chemistry Journal Award, ACS-WCC Rising Star Award, ACS DOC Early Academic Investigator Award, MSU Distinguished Alumni Award, and the UW-Vilas Mid-Career and UW2020 Awards. She was named a 2016 Kavli Fellow and received a 2019 Gabor A. and Judith K. Somorjai Miller Visiting Professor Award at Berkeley. She is the author of over 100 papers and patents. Research in the Schomaker group spans a broad range of interests, inspired by early efforts to solve challenges hampering the study of densely functionalized, stereochemically complex amine-containing natural products that bind to the ribosome, as well as explore new amine chemical space. In this context, we developed a suite of versatile oxidative allene amination tools to prepare diverse analogues of known bioactive molecules and identify new sp3 nitrogen-containing scaffolds with activities against malaria, tuberculosis, and cancer. Our design of a new class of cycloalkynes for cell labeling studies, where the polarizability of the alkyne is tunable to achieve bioorthogonality with a variety of coupling partners, has opened up opportunities for exciting collaborations. Our interest in catalyst-controlled C–H functionalization led us to describe the first examples of controlling the diverse coordination geometry of silver-supported nitrenes to achieve chemo-, site- and enantioselective amidations of a range of diverse C–H bonds. |