Recent advances and prospects in the metal-free synthesis of quinolines

Abstract

Quinolines are a predominant class of nitrogen containing heterocycles with wide applications in the medical and industrial fields. Owing to their significant importance, numerous synthetic protocols have emerged in the past two centuries. Metal-free synthesis of quinolines has recently gained attention in view of toxic metal-free druggable quinoline synthesis. In this context, this review focuses on the recent advances in the metal-free synthesis of quinolines and covers all the reports from 2016–2020.