Issue 36, 2020

Electrochemical asymmetric synthesis of biologically active substances

Abstract

Electrically driven oxidation and reduction reactions are well-established methods for synthesis even in the chemical industry, but asymmetric versions are still few. The mild conditions used, atom efficiency and low cost make these reactions a very attractive alternative to other methods of synthesis. Very fine tuning can be achieved based on minute changes in potentials, allowing only one functional group in a molecule to react in the presence of several others, which is ideal for applications in total synthesis. In this review, the literature in the field of asymmetric synthesis of biologically active substances over the last 10 years is surveyed.

Graphical abstract: Electrochemical asymmetric synthesis of biologically active substances

Article information

Article type
Review Article
Submitted
10 Jul 2020
Accepted
15 Aug 2020
First published
28 Aug 2020

Org. Biomol. Chem., 2020,18, 7026-7055

Electrochemical asymmetric synthesis of biologically active substances

A. M. F. Phillips and A. J. L. Pombeiro, Org. Biomol. Chem., 2020, 18, 7026 DOI: 10.1039/D0OB01425G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements