Issue 7, 2020
From the journal:

Organic & Biomolecular Chemistry

Visible-light-driven metal-free aerobic synthesis of highly diastereoselective phosphinoylpyrroloindoles†

Ramesh Gorre,‡ab   Damodar Enagandhula,‡a   Sridhar Balasubramanianbc  and  Srirama Murthy Akondi ORCID logo *ab  

* Corresponding authors

a Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India
E-mail: sriramakondi@iict.res.in, sriramiict@gmail.com

b Academy of scientific and innovative research (AcSIR), Ghaziabad 201002, India

c Department of Analytical Chemistry, CSIR-IICT, Hyderabad 500007, India

Abstract

A visible-light-driven metal-free phosphorus radical mediated construction of 2-phosphinoyl-3H-pyrrolo[1,2,a]indoles is described. This mild tandem phosphinoylation/cyclization protocol utilizes air as a green oxidant and proceeds in a short span of time at room temperature with high functional group tolerance, and excellent chemo- and diastereoselectivity.

Graphical abstract: Visible-light-driven metal-free aerobic synthesis of highly diastereoselective phosphinoylpyrroloindoles

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Article information

DOI
https://doi.org/10.1039/C9OB02730K
Article type
Communication
Submitted
24 Dec 2019
Accepted
24 Jan 2020
First published
27 Jan 2020

Org. Biomol. Chem., 2020,18, 1354-1358

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Visible-light-driven metal-free aerobic synthesis of highly diastereoselective phosphinoylpyrroloindoles

R. Gorre, D. Enagandhula, S. Balasubramanian and S. M. Akondi, Org. Biomol. Chem., 2020, 18, 1354 DOI: 10.1039/C9OB02730K

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