Peptide bond cleavage in the presence of Ni-containing particles

Abstract

NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni²⁺ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their molar equivalent of soluble Ni(II) salt. These findings highlight the efficacy of delivery of toxic Ni²⁺ by these environmentally available particles.