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Correction: Leishmania infantum isolates exhibit high infectivity and reduced susceptibility to amphotericin B
Paula
Faral-Tello
a,
Gonzalo
Greif
a,
Dinora
Satragno
b,
Yester
Basmadjián
c and
Carlos
Robello
*ad
aLaboratorio de Interacciones Hospedero Patógeno, Unidad de Biología Molecular, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, 11400, Uruguay
bCentro Hospital Veterinario, Facultad de Veterinaria, Universidad de la República, Uruguay
cDepartamento de Parasitología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
dDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. E-mail: robello@pasteur.edu.uy
First published on 6th August 2020
Abstract
Correction for ‘Leishmania infantum isolates exhibit high infectivity and reduced susceptibility to amphotericin B’ by Paula Faral-Tello et al., RSC Med. Chem., 2020, DOI: 10.1039/d0md00073f.
The authors regret that there were some errors in their manuscript. In section 3, Results and discussion, the second paragraph starting with ‘After species typing…’ should be replaced by the following text: After species typing with hsp70-RFLP (Fig. S1), growth curves were determined including the reference strain LPC-RPV, and the five isolates. When seeded at 5 × 106 parasites per mL, all strains showed equivalent exponential growth until approximately 140 hours of culture (1 × 108 p mL−1) when entering the lag phase of growth (Fig. S2). These parameters of exponential growth were used for further IC50 experiments. Five drugs were tested in vitro: nifurtimox, miltefosine, glucantime, AmB and mevinoline. For each drug the IC50 was determined and the values are shown in Table 2, and the dose response curves in Fig. S2. Behavior in the drug response curves and IC50 values for nifurtimox, miltefosine and glucantime are very similar, and no significant differences are found among the strains, values are in the range of 6, 4 and 50 μM, respectively.
In section 3, Results and discussion, the sixth paragraph starting with ‘Our second focus…’, should have the following sentence added at the end of the paragraph: All values are summarized in Fig. 1D.
Fig. 2 should be deleted from the manuscript as its content is shown in Fig. 1.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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