Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

Yihang Chen; Shiming Zhang; Qingyu Cui; Jiahua Ni; Xiaochen Wang; Xuanbing Cheng; Halima Alem; Peyton Tebon; Chun Xu; Changliang Guo; Rohollah Nasiri; Rosalia Moreddu; Ali K. Yetisen; Samad Ahadian; Nureddin Ashammakhi; Sam Emaminejad; Vadim Jucaud; Mehmet R. Dokmeci; Ali Khademhosseini

doi:10.1039/D0LC00446D

Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing†

Yihang Chen,^abc Shiming Zhang,*^abde Qingyu Cui,^f Jiahua Ni,^abd Xiaochen Wang,^abd Xuanbing Cheng,^cg Halima Alem,

^abdhi Peyton Tebon,

^abd Chun Xu,

^abd Changliang Guo,^f Rohollah Nasiri,^abdj Rosalia Moreddu,

^kl Ali K. Yetisen,

^l Samad Ahadian,^abd Nureddin Ashammakhi,^abdm Sam Emaminejad,

^dg Vadim Jucaud,^e Mehmet R. Dokmeci

^abem and Ali Khademhosseini

*^abdemn

Author affiliations

* Corresponding authors

^a Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA

^b California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA

^c Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA

^d Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA
E-mail: szhang@eee.hku.hk, khademh@terasaki.org

^e Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA

^f Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

^g Department of Electrical and Computer Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA

^h Institut Jean Lamour, Université de Lorraine-CNRS, 54000 Nancy, France

ⁱ Institut Universitaire de France, France

^j Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran

^k School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

^l Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

^m Department of Radiology, University of California-Los Angeles, Los Angeles, CA 90095, USA

ⁿ Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA

Abstract

Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in a dehydrated channel, indicating that the motion of eye-blinking may help tears flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na⁺ sensing capabilities were demonstrated in these microchannels. This work paves the way for the development of microengineered poly(HEMA) hydrogels for various biomedical applications such as eye-care and wearable biosensing.

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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing†

Abstract

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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

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