Issue 11, 2020
From the journal:

Green Chemistry

Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes†

José S. S. Neto,*a   Renata A. Balaguez,b   Marcelo S. Franco, ORCID logo a   Victor C. de Sá Machado,a   Sumbal Saba, ORCID logo c   Jamal Rafique, ORCID logo d   Fábio Z. Galetto*b  and  Antonio L. Braga ORCID logo *a  

* Corresponding authors

a LabSelen - Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
E-mail: zeneto.qmc@gmail.com, braga.antonio@ufsc.br

b Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
E-mail: galetto.f.z@ufsc.br

c Centro de Ciências Naturais e Humanas-CCNH, Universidade Federal do ABC, Santo André, SP, Brazil

d Instituto de Química, Universidade Federal do Mato Grosso do Sul – UFMS, Campo Grande, MS, Brazil

Abstract

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach.

Graphical abstract: Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

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Article information

DOI
https://doi.org/10.1039/D0GC00137F
Article type
Communication
Submitted
12 Jan 2020
Accepted
17 Mar 2020
First published
18 Mar 2020

Green Chem., 2020,22, 3410-3415

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Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

J. S. S. Neto, R. A. Balaguez, M. S. Franco, V. C. de Sá Machado, S. Saba, J. Rafique, F. Z. Galetto and A. L. Braga, Green Chem., 2020, 22, 3410 DOI: 10.1039/D0GC00137F

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