Issue 90, 2020

Copper-catalyzed oxidative decarboxylative alkylation of cinnamic acids with 4-alkyl-1,4-dihydropyridines

Abstract

We have developed a new oxidative decarboxylation of cinnamic acids with 4-alkyl-1,4-dihydropyridines to construct C(sp3)–C(sp2) bonds in the presence of copper catalyst and dicumyl peroxide (DCP). A variety of internal alkenes have been obtained with mild conditions, broad substrate scope and excellent functional group tolerance. This method has significant potential for application by using inexpensive and stable cinnamic acids instead of alkenyl halides and nitro-olefins.

Graphical abstract: Copper-catalyzed oxidative decarboxylative alkylation of cinnamic acids with 4-alkyl-1,4-dihydropyridines

Supplementary files

Article information

Article type
Communication
Submitted
23 Sep 2020
Accepted
16 Oct 2020
First published
16 Oct 2020

Chem. Commun., 2020,56, 14055-14058

Copper-catalyzed oxidative decarboxylative alkylation of cinnamic acids with 4-alkyl-1,4-dihydropyridines

D. Zhang, Z. Tang, X. Ouyang, R. Song and J. Li, Chem. Commun., 2020, 56, 14055 DOI: 10.1039/D0CC06401G

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