Issue 87, 2020
From the journal:

Chemical Communications

Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying†

Ignacio Luz, ORCID logo ‡a   Ian E. Stewart, ORCID logo ‡*a   Ninell P. Mortensen ORCID logo b  and  Anthony J. Hickey ORCID logo a  

* Corresponding authors

a Center for Engineered Systems, RTI International, USA
E-mail: istewart@rti.org

b Center for Analytical Chemistry and Pharmaceutics, RTI International, USA

Abstract

Inhalable metal organic framework (MOF) aerosols have been developed via spray drying as a therapy for multi-drug resistant (MDR) tuberculosis (TB). The CuPOA2 (pyrazinoate acid) MOFs can be tailored to exhibit a respirable mass median aerodynamic diameter (MMAD) of 2.6 μm. This method is repeated to manufacture Gd0.1Cu0.9(POA)2 MOFs for inhalable theragnostics.

Graphical abstract: Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0CC05471B
Article type
Communication
Submitted
11 Aug 2020
Accepted
28 Sep 2020
First published
29 Sep 2020

Chem. Commun., 2020,56, 13339-13342

Permissions

Request permissions

Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying

I. Luz, I. E. Stewart, N. P. Mortensen and A. J. Hickey, Chem. Commun., 2020, 56, 13339 DOI: 10.1039/D0CC05471B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements