Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van-Nghia Nguyen; Sang Jun Park; Sujie Qi; Jeongsun Ha; Seonye Heo; Yubin Yim; Gain Baek; Chang Su Lim; Dong Joon Lee; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/D0CC04644B

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer†

Van-Nghia Nguyen,

‡^ab Sang Jun Park,‡^c Sujie Qi,

‡^b Jeongsun Ha,^b Seonye Heo,^b Yubin Yim,^b Gain Baek,^b Chang Su Lim,^c Dong Joon Lee,^c Hwan Myung Kim

*^c and Juyoung Yoon

*^b

Author affiliations

* Corresponding authors

^a Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam

^b Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea
E-mail: jyoon@ewha.ac.kr

^c Department of Chemistry and Energy Systems Research, Ajou University, Suwon 16499, Korea
E-mail: kimhm@ajou.ac.kr

Abstract

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular, NIS-Me and CRNS display outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

Chemical Communications

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer†

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Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

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