Issue 73, 2020
From the journal:

Chemical Communications

Cancer cell death using metabolic glycan labelling techniques†

Sang-Hyun Park,a   Hyoje Jung,a   Hosoowi Lee,a   Tae Min Kim,b   Jin Won Cho,c   Woo-Dong Jang, ORCID logo a   Ji Young Hyun*ad  and  Injae Shin ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea
E-mail: injae@yonsei.ac.kr

b Department of International Medicines, Seoul National University Hospital, Seoul 03080, Republic of Korea

c Department of Systems Biology, Yonsei University, Seoul 03722, Republic of Korea

d Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea
E-mail: hyunjy@krict.re.kr

Abstract

Herein we describe a method for inducing cancer cell death, which relies on the use of a H2O2-responsive glycan metabolic precursor in conjunction with antibody-dependent cellular cytotoxicity (ADCC) or photodynamic therapy (PDT).

Graphical abstract: Cancer cell death using metabolic glycan labelling techniques

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Article information

DOI
https://doi.org/10.1039/D0CC04474A
Article type
Communication
Submitted
29 Jun 2020
Accepted
19 Aug 2020
First published
19 Aug 2020

Chem. Commun., 2020,56, 10650-10653

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Cancer cell death using metabolic glycan labelling techniques

S. Park, H. Jung, H. Lee, T. M. Kim, J. W. Cho, W. Jang, J. Y. Hyun and I. Shin, Chem. Commun., 2020, 56, 10650 DOI: 10.1039/D0CC04474A

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