Issue 70, 2020
From the journal:

Chemical Communications

A DNAzyme cascade for amplified detection of intracellular miRNA†

Yanan Wu,a   Jing Li,a   Ke Quan,b   Xiangxian Meng,a   Xiaohai Yang, ORCID logo a   Jin Huang ORCID logo *a  and  Kemin Wang ORCID logo a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, China
E-mail: jinhuang@hnu.edu.cn

b School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, China

Abstract

Inspired by the natural enzyme cascade reaction, an artificial DNAzyme cascade system is developed for the amplified detection of intracellular miR-141. The results showed that the method enormously enhanced the readout of the fluorescence signal and achieved a femtomolar detection limit.

Graphical abstract: A DNAzyme cascade for amplified detection of intracellular miRNA

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Article information

DOI
https://doi.org/10.1039/D0CC02847A
Article type
Communication
Submitted
20 Apr 2020
Accepted
17 Jul 2020
First published
17 Jul 2020

Chem. Commun., 2020,56, 10163-10166

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A DNAzyme cascade for amplified detection of intracellular miRNA

Y. Wu, J. Li, K. Quan, X. Meng, X. Yang, J. Huang and K. Wang, Chem. Commun., 2020, 56, 10163 DOI: 10.1039/D0CC02847A

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