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Correction: Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design

Andrew M. Beekman*a, Marco M. D. Cominettia, Samuel J. Walpolea, Saurabh Prabhua, Maria A. O’Connella, Jesus Anguloa and Mark Searcey*ab
aSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR47TJ, UK. E-mail: A.Beekman@uea.ac.uk; M.Searcey@uea.ac.uk
bSchool of Chemistry, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR47TJ, UK

Received 4th April 2019 , Accepted 4th April 2019

First published on 14th May 2019


Correction for ‘Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design’ by Andrew M. Beekman et al., Chem. Sci., 2019, DOI: 10.1039/c9sc00059c.


The authors regret that the structures of compounds 2, 3, 10 and 11 are incorrect in the original article. The correct structures are presented in the updated version of Table 1 below.
Table 1 IC50 values for inhibition of the binding of FAM-p4 to hDM2 and hDMX of small molecules.a A green background indicates the compound was designed for and was selective to the same protein. Yellow indicates the compound is a dual inhibitor. A red background indicates the compound was designed for one protein but was selective for the other protein
a IC50 values determined by non-linear regression of at least three independent experiments (see ESI, pg 10). Errors are 95% confidence intervals (CI). Fmoc, 9-fluorenylmethylcarbonyl.
image file: c9sc90088h-u1.tif


The original ESI was replaced by a correspondingly revised version on 1st May 2019 to reflect these changes.

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Footnote

Electronic supplementary information (ESI) available: See DOI: 10.1039/c9sc00059c

This journal is © The Royal Society of Chemistry 2019