Enrica Gianotti*a,
Ivana Miletto
a,
Chiara Ivaldia,
Geo Paula,
Leonardo Marchese
a,
Marta Meazza
b,
Ramon Rios
b and
Robert Raja
b
aDepartment of Science and Technological Innovation, Università del Piemonte Orientale, V. T. Michel 11, I-15121 Alessandria, Italy. E-mail: enrica.gianotti@uniupo.it
bSchool of Chemistry, University of Southampton, University Road, Southampton, SO17 1BJ, UK
First published on 31st October 2019
Hybrid materials have been synthesized by anchoring a N-heterocyclic carbene (NHC) precursor on different inorganic zeolitic supports with hierarchical porosity, in particular hierarchical HZSM-5 and SAPO-5. Hierarchical porous inorganic supports have been obtained both by top-down and bottom-up approaches and the role of hierarchical porosity has been evaluated. A detailed physico-chemical characterization has been performed on the organic–inorganic hybrids using a multi-technique approach (XRD, volumetric and thermogravimetric analysis, ssNMR and FTIR) in order to establish a structure–property relationship. The hybrids were tested in the benzoin condensation reaction of furfural, a base catalyzed reaction.
Silylated N-heterocyclic carbene (NHC) precursor, carrying a long chain (C12) substituent at the N atom, was anchored on silanol groups (Si–OH) present in the mesopores of the calcined hierarchical HZSM-5 and SAPO-5 supports as represented in Scheme 1. The role of the long-chain alkyl is to avoid NHC deactivation by dimerization and to sterically protect the NHC catalytic site.22 The acronyms of the hybrid catalysts, together with their elemental analysis and organic loadings are reported in Table 1. The organic loading is almost similar for both the hybrid materials.
Acronyms of the hybrids | C% | H% | N% | Organic loading (mmol g−1) |
---|---|---|---|---|
NHC/HP-HZSM-5 | 9.15 | 1.55 | 0.56 | 0.20 |
NHC/HP-SAPO-5 | 7.61 | 1.55 | 0.62 | 0.25 |
In order to confirm phase purity, crystallinity and retention of the structural properties of the inorganic supports upon the carbene anchoring procedure, XRD analysis on hybrid catalysts has been performed. The XRD diffraction patterns of the NHC/HP-HZSM-5 and NHC/HP-SAPO-5 (Fig. S1 and S2 in the ESI†) showed the same diffraction peaks present before the NHC anchoring procedure confirming the retention of the structural properties of the supports. In addition, the MFI and AFI structures typical of ZSM-5 and SAPO-5 are evidenced in the hierarchical supports and hybrid catalysts.
Thermogravimetric analysis was performed in order to gain insight into the organic content and the thermal stability of the anchored NHC precursor on hierarchical supports (Fig. 1). The first weight loss observed in all materials at around 30–180 °C can be associated to the removal of physisorbed water and highlighted that the HP-SAPO-5 is a more hydrophilic support with respect to the HP-HZSM-5 due to the higher amount of physisorbed water. At higher temperatures, flat weight loss profiles of the hybrids changed into a rapidly declining profile corresponding to the decomposition of the organic NHC. The organic content, calculated from the weight loss in the 180–1000 °C range, due to the decomposition of the anchored NHC is reported in Table 2 and is in line with the data from elemental analysis. In addition, from the DTG curves, it is possible to observe that the temperature of weight loss due to the anchored NHC is around 270 °C for both hybrids.
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Fig. 1 TGA/DTG curves of (A) plain HP-HZSM-5 (black curves) and NHC/HP-HZSM-5 (red curves) and of (B) plain HP-SAPO-5 (black curves) and NHC/HP-SAPO-5 (red curves). |
N2 adsorption/desorption at 77 K on both hierarchical supports revealed type-IV isotherms typical of mesoporous materials (Fig. 2A), while microporous analogues have type-I isotherms.13,23 Pore size distributions (Fig. 2B) were obtained by NLDFT (non-localized density functional theory) method by analyzing the desorption branch of the isotherms.24,25 Hierarchical inorganic supports exhibited, a part of the micropores typical of the MFI and AFI structures, mesopores at 35 and 50 Å. Details of the specific surface area and pore volumes, determined by the NLDFT, are summarized in Table 3.
Samples | SBET (m2 g−1) | SDFT (m2 g−1) | Smicro (m2 g−1) | Smeso (m2 g−1) | Vtot DFT (cm3 g−1) | Vmicro (cm3 g−1) | Vmeso (cm3 g−1) |
---|---|---|---|---|---|---|---|
HP-SAPO-5 | 573 | 508 | 215 | 293 | 0.49 | 0.05 | 0.44 |
HP-HZSM-5 | 500 | 731 | 516 | 215 | 0.80 | 0.10 | 0.70 |
Volumetric data support the successful preparation of hierarchical inorganic supports and indicate the coexistence of multiple levels of porosity. HP-HZSM-5 showed a higher mesopore volume (Vmeso) and total pore volume (Vtot) with respect HP-SAPO-5. Upon NHC anchoring on the hierarchical supports, the N2 adsorption capacity decreases together with the specific surface area and pore volume (Fig. S3†), confirming that the NHC moiety is anchored inside the pores. Nevertheless, the textural properties of NHC/HP-HZSM-5 are less affected by the NHC presence with respect NHC/HP-SAPO-5 due to the different framework architectures and to the synthetic method used to prepare the hierarchical supports.
A combined study coupling FTIR and ssNMR spectroscopies has been performed to elucidate the interaction of the organic NHC moiety with the inorganic supports and to evidence the OH population before and after the organic grafting in order to understand the role of the hierarchical supports in stabilizing NHC molecules and the fraction of the OH involved in the NHC grafting.26
In order to establish if the Si–OH group in NHC/HP-HZSM-5 have been consumed upon NHC grafting and if the bridging Si–OH–Al groups (Brønsted acid sites, BAS) typical of the HZSM-5 and SAPO-5 frameworks have been retained after the grafting procedure, FT-IR spectra of NHC/HP-HZSM-5, NHC/HP-SAPO-5 and their inorganic analogue HP-HZSM-5 and HP-SAPO-5 were recorded (Fig. 3 and 4). All samples were treated 180 °C in vacuum to remove adsorbed water. In the spectra of plain HP-HZSM-5 (Fig. 3, black curve) and HP-SAPO-5 (Fig. 4, black curve), the signal at 3745 cm−1, assigned to the O–H stretching mode of isolated Si–OH, disappeared upon NHC grafting (red curves), confirming that all the Si–OH anchoring sites have been consumed. The broad band at 3611 cm−1, in the HP-HZSM-5 spectrum, is assigned to O–H stretching mode of Brønsted acid sites belonging to zeolite framework.13 In contrast, HP-SAPO-5 exhibits two well separated bands at 3630 and 3515 cm−1 associated to Brønsted acid sites in different position inside the AFI framework.27 The high frequency band is due to sites located in the 12-ring channels, while the band at 3515 cm−1 can be attributed to bridging OH located in the 6-ring channels.28,29 The signals of Brønsted acid sites are still visible in the spectra of NHC/HP-HZSM-5 and NHC/HP-SAPO-5, meaning that these acid groups are not involved in the NHC grafting. At lower frequencies, the signals, present only in the NHC-hybrids spectra (Fig. 3 and 4, red curves), are due to the organic component of the hybrids. In particular, absorptions arising from asymmetric and symmetric C–H stretching modes in the aromatic ring occurs in the region of 3150–3000 cm−1. In the region 3000–2800 cm−1, C–H stretching signals of aliphatic compounds are observed: at 2960 cm−1 and 2924 cm−1 are visible the asymmetric stretching vibrations of –CH3 and –CH2 groups respectively, while the symmetric stretching modes are observed at 2855 cm−1 for both –CH2 and –CH3. In the region between 1650–1400 cm−1, the C–C ring stretching modes are present. These signals are overlapped with the –CH2 and –CH3 bending vibrations of aliphatic compounds (1460–1350 cm−1). The C–N stretching mode characteristic of the imidazole ring is observed at 1565 cm−1.19,30
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Fig. 3 FTIR spectra of plain HP-HZSM-5 (black curve) and NHC/HP-HZSM-5 (red curve) outgassed at 180 °C. |
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Fig. 4 FTIR spectra of plain HP-SAPO-5 (black curve) and NHC/HP-SAPO-5 (red curve) outgassed at 180 °C. |
The thermal stability of NHC grafted on the different hierarchical supports was investigated by FTIR spectroscopy experiments carried out at different outgassing temperatures (Fig. 5 and 6). The FTIR signals due to C–H stretching modes (3050–2800 cm−1) and C–C ring modes (1650–1400 cm−1) of NHC anchored in the different hybrids upon outgassing at increasing temperature decreased in intensity together with the band due to the C–N stretching mode characteristic of the imidazole ring at 1565 cm−1. By monitoring this signal, it is possible to determine the organic counterpart stability of the grafted compound during the thermal treatment. This signal decreases significantly in intensity at 250 °C and totally disappears at 400 °C.
Together with FTIR spectra, 1H MAS NMR spectroscopy provided direct information about the different proton sites present in the hierarchical inorganic supports (Fig. 7). The proton spectra of calcined and dehydrated hierarchical supports consist of contributions from isolated external silanols (1.8–2.0 ppm), hydroxyl units bound to Lewis acid sites (LAS) and extra framework aluminum species (EFAl) through hydrogen bonding (2.4–2.8 ppm), Brønsted acid sites (3.8–5.0 ppm) and hydrogen-bonded hydroxyls (5.8 ppm).31–33 In the case of HP-SAPO-5, two different signals, due to Brønsted acid sites, are evidenced in agreement with the FTIR data. Quantitative representations of various protonic species are shown in Table 4. Furthermore, 27Al TRAPDOR NMR spectra were recorded to separate contribution from silanols and Brønsted acid sites (Fig. S4†). The 1H/27Al TRAPDOR NMR method allows to differentiate protons that are dipolar coupled to nearby Al atoms, such as Brønsted and Lewis acid sites as well as Al–OH, from all other protons.34 Two 1H spin-echo NMR spectra were collected, without and with 27Al irradiation. While the former displays all the protons in the sample, a difference spectrum will show only protons in close vicinity to 27Al. These data clearly demonstrate that HP-HZSM-5 has a higher amount of available Si–OH groups with respect HP-SAPO-5 and low amount of Brønsted acid sites.
νOH/cm−1 | 1H chemical shift (δ)/ppm | Assignments | 1H species (%) | |
---|---|---|---|---|
HP-HZSM-5 | HP-SAPO-5 | |||
3745 | 1.8–2.1 | Isolated Si–OH | 29 | 15 |
2.4–2.5 | OH bound to lewis acid and EFAl species (LAS) | 26 | 22 | |
3618–3615 | 3.8 | Brønsted acid sites (BAS) | 26 | 32 |
3520 | 4.8 | Brønsted acid sites (BAS) in small cages | — | 26 |
≈3500 | 5.8 | H-bonded species | 19 | 5 |
Upon NHC grafting, the peak at 1.8 ppm due to Si–OH is not visible while the signals of the Brønsted acid site of the inorganic frameworks are still present in the 1H MAS NMR spectra for both hybrids (Fig. 8, left panel), confirming that silanols are used to anchor the NHC precursor and the Brønsted acid sites are not affected by its presence. The signals in the 0–3 ppm range due to the aliphatic chain on the N-pyrrolic ring and a broad signal from 6.5 to 11 ppm due to aromatic protons are also visible. The imidazole proton, the active site of NHC, which in the liquid phase is at 11 ppm, is also present in this range. The successful grafting of the silylated NHC moiety was additionally verified by solid-state 13C CPMAS NMR (Fig. 8, right panel) and the signals due to C in aliphatic chains are in the 20–35 ppm range. Terminal methyl and methylene carbons as well as the propylic linker carbons resonate in the 5–15 ppm range. At around 50 ppm the signal of the two N–CH2 groups is visible, while the signals of the carbon atoms of the benzimidazole moiety are in the 110–140 ppm range.
The chemical environment of the framework atoms in hierarchical supports and NHC-containing hybrids was evaluated by 27Al, 31P and 29Si MAS NMR (Fig. S5 and S6†). The 29Si CP MAS NMR spectra of NHC/HP-ZSM-5 (Fig. S5†) exhibit signals due to Q sites −112 (Q4(0Al)), −105 (Q4(1Al)), −100 (Q3(0Al)) and −90 (Q2(0Al) ppm) owing to tetrahedral framework Si coordinated to four, three, and two Si atoms and signals due to T sites at −65 ppm (T3, [RSi(OSi)3]) and at −57 ppm (T2, [RSi(OSi)2OH]), confirming the success of the grafting procedure. The 27Al MAS NMR spectra evidenced the presence of tetrahedrally coordinated Al (AlIV, signal at ca. 54 ppm). Between 1–9 ppm a broad signal is visible due to six-coordinated Al sites (AlVI), the presence of these octahedral Al sites is due to the desilication process to obtain the hierarchical framework.13 In the case of HP-SAPO-5, the 31P MAS NMR spectra are also recorded (Fig. S6†). The 29Si CP MAS NMR spectra of NHC/HP-SAPO-5 reveals Q and T sites, the relative intensity of the Q sites is different from that of HP-HZSM-5, revealing a different degree of defectivity. The 27Al MAS NMR spectra evidenced the presence of tetrahedrally coordinated Al (Al(OP)4, signal at ca. 37 ppm) and no signal due to six-coordinated Al sites are present. Finally, the 31P MAS NMR spectra exhibit a single peak at −30.5 ppm assigned to tetrahedrally-coordinated P atoms. Since both 27Al and 31P MAS NMR spectra have only a single resonance, it is possible to confirm strictly alternation of Al and P atoms at the T-positions of the SAPO-5 framework.
NHC based hybrid catalysts were tested in the reaction of self-condensation of furfural (Scheme 2), a carbene catalyzed reaction at room temperature.35 The reaction starts with the deprotonation of the benzimidazole moiety by the organic base (1,8-diazabicyclo[5.4.0]undec-7-ene, DBU), forming the active carbene catalyst. The hybrid catalyst reacts with one molecule of furfural, forming the Breslow intermediate, which undergoes a nucleophilic attack to another non-activated molecule of furfural, with formation of the furoin as final product. We envisage the solid acid sites present on the hierarchical HP-ZSM-5 and HP-SAPO-5 supports can coordinate with the substrate (via the carbonyl group), thereby increasing their electrophilicity, which favours the nucleophilic attack of the NHC. Preliminary results showed better catalytic performances of NHC/HP-HZSM-5 hybrid with respect NHC/HP-SAPO-5 (Fig. 9). In fact, almost 98% yield was reached when NHC/HP-ZSM-5 hybrid is used as heterogeneous catalyst. Both hybrid catalysts can be recycled and reused with the NHC/HP-HZSM-5 showing a more sustained performance post recycling.
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Fig. 9 Catalytic activity and recycling tests of NHC-based hybrids in benzoin condensation reaction. The yield (%) is reported after 20 h of reaction. |
Control experiments with hierarchical HP-ZSM-5 and HP-SAPO-5 (without the anchored NHC) have been carried out and we did not observe any reactivity with these catalysts. This further emphasises the role of the anchored N-heterocyclic carbene in the catalytic process.
The gel was transferred to a Teflon-lined stainless-steel autoclave and crystallized at 473 K for 60 h under autogenous pressure. The solid product from autoclave was then recovered by filtration and washed with water. The as-prepared product was dried in air at 373 K and calcined in a tube furnace under air flow at 873 K for 16 h to remove organic surfactant and micropore template, producing a white crystalline solid.14
Benzimidazole (8.46 mmol) was added slowly to a suspension of NaH (1 equiv.) in THF (6 ml) under argon at 0 °C and the solution was left stirring for 30 min at room temperature. Then, dodecylbromide (8.46 mmol) was added dropwise and left to reflux for 24 h. Then the solution was filtered and washed with CH2Cl2 over a pad of celite. Then the solvent was evaporated and the product was purified via chromatographic column. Yield: 97%. 1H-NMR (CDCl3, 500 MHz, ppm): 0.90 (t, –CH2–), 1.25–1.35 (m, N–CH2–CH2–
–CH3), 1.89 (q, N–CH2–
–(CH2)9–CH3), 4.17 (t, N–
–CH2–(CH2)9–CH3), 7.83 (m, Ar), 7.90 (s, N–
–N). 13C-NMR (CDCl3, 125 MHz, ppm): 14 (–N–(CH2)11–
), 22 (–N–(CH2)10–
–CH3), 26.8, 29.1, 29.3, 29.4, 29.58, 29.6, 29.85 (aliphatic chain), 31.9 (N–CH2–
–(CH2)9), 45.12 (N–
–CH2–(CH2)9), 109.65, 120.38, 121.98, 122.75, 133.84, 143.90 (aromatic except N–CH–N), 142.93 (N–
–N).
After the alkylation of benzimidazole, the carbene precursor was silylated; this procedure is necessary to have siloxane groups able to anchor to the Si–OH of the inorganic supports. The NHC-silylated precursor was prepared in accordance to previously reported literature data (Scheme 4).22
The 1-alkylated benzimidazole (8.20 mmol) was dissolved in ACN solvent (12 ml), then 1-iodo-3(methoxysilyl)propane (12.3 mmol) was added and left stirring for 24 h under argon. Once the reaction was finished, the product was washed with anhydrous pentane. Yield: 95%. 1H-NMR (CDCl3, 500 MHz, ppm): 0.80 (t, –CH2–), 0.699 (O–Si–
–CH2), 1.11–1.41 (m, N–CH2–CH2–
–CH3), 2 (q, N+–CH2–
–CH2–Si), 2.11 (q, N–CH2–
–(CH2)9–CH3), 3.55 (O–
), 4.53 (t, N–
–CH2–(CH2)9–CH3), 4.58 (t, N+–
–CH2–CH2–Si), 7.58–7.69 (m, Ar), 11.1 (s, N–
–N). 13C-NMR (CDCl3, 125 MHz, ppm): 14 (–N–(CH2)11–
), 22.3, 22.7, 23.3, 26.6, 29, 29.31, 29.37, 29.49, 29.5, 29.57, 31.9, 34.1 (aliphatic chain), 50.8 (CH2–Si–O–
), 113, 113.24, 127.21, 127.24 (aromatic except N–CH–N), 141.94 (N–
–N).
X-Ray powder diffraction (XRD) patterns were obtained using an ARL XTRA48 diffractometer with Cu Kα radiation (λ = 1.54062 Å).
N2 physisorption measurements were carried out at 77 K in the relative pressure range from 1 × 10−6 to 1 P/P0 by using a Quantachrome Autosorb1MP/TCD instrument. Prior to the analysis, the hierarchical supports were outgassed at 423 K for 3 h (residual pressure lower than 10−6 torr). Specific surface areas were determined using the Brunauer–Emmett–Teller equation, in the relative pressure range from 0.01 to 0.1 P/P0. The desorption branch of the N2 physisorption isotherm was analyzed by means of the NLDFT (non-localized density functional theory) method, to obtain the pore size distribution of the materials.
Thermogravimetric analyses were carried out on a Mettler TGA/SDTA 851e instrument, in nitrogen. The samples were heated from 30 to 1000 °C at a heating rate of 20°C min−1 under a gas flow rate of 60 ml min−1.
FTIR spectra of self-supporting pellets at variable temperature were collected under vacuum conditions (residual pressure < 10−4 mbar) using a Bruker Equinox 55 spectrometer equipped with a pyroelectric detector (DTGS type) with a resolution of 4 cm−1. FTIR spectra were normalized with respect the pellet weight.
1H-NMR and 13C-NMR were recorded with a Bruker DPX400 NMR. Chemical shifts (δ) are reported in ppm relative to residual solvent signals (CHCl3, 7.26 ppm for 1H NMR; CDCl3, 77.15 ppm for 13C NMR).
Solid-state NMR spectra were acquired on a Bruker Avance III 500 spectrometer and a wide bore 11.7 Tesla magnet with operational frequencies for 1H, 29Si, 27Al, 31P and 13C of 500.13, 99.35, 130.32, 202.45 and 125.77 MHz, respectively. A 4 mm triple resonance probe (in double resonance mode) with MAS was employed in all the experiments. The samples were packed on a Zirconia rotor and spun at a MAS rate between 10 and 15 kHz. The magnitude of radio frequency (RF) field was 100, 83, 42 kHz, for 1H, 31P and 29Si, respectively, while a π/12 pulse was used for the 27Al MAS experiment. The relaxation delay between accumulations was 5, 30, 60, 1 s for 1H, 31P, 29Si and 27Al, respectively. For the 13C and 29Si Cross Polarization (CP) MAS experiments, the RF fields of 55 and 28 kHz were used for initial proton excitation and decoupling, respectively. During the CP period the 1H RF field was ramped using 100 increments, whereas the 13C/29Si RF fields were maintained at a constant level. During the acquisition, the protons are decoupled from the carbons/silicons by using a two-pulse phase-modulated (TPPM) decoupling scheme. A moderate ramped RF field of 62 kHz was used for spin locking, while the carbon/silicon RF field was matched to obtain optimal signal and the CP contact time of 2 ms were used. All chemical shifts are reported using δ scale and are externally referenced to TMS for 1H, 13C and 29Si, 1 M solution of AlCl3 for 27Al and ammonium dihydrogen phosphate for 31P.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c9ra07516j |
This journal is © The Royal Society of Chemistry 2019 |