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DOI: 10.1039/C9QO90072A (Correction) Org. Chem. Front., 2019, 6, 3042-3042

Correction: (E)-Selective Friedel–Crafts acylation of alkynes to β-chlorovinyl ketones: defying isomerizations in batch reactions by flow chemistry approaches

Hyungmo Koo , Hun Young Kim * and Kyungsoo Oh *
Center for Metareceptome Research, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak, Seoul 06974, Republic of Korea. E-mail: kyungsoooh@cau.ac.kr; hunykim@cau.ac.kr

Received 22nd July 2019 , Accepted 22nd July 2019

First published on 29th July 2019

Abstract

Correction for ‘(E)-Selective Friedel–Crafts acylation of alkynes to β-chlorovinyl ketones: defying isomerizations in batch reactions by flow chemistry approaches’ by Hyungmo Koo et al., Org. Chem. Front., 2019, 6, 1868–1872.

There was an error within the Table 1 footnote: the quantity of reagent 1a was incorrectly given as 0.05 mmol, and should instead be 0.5 mmol. The corrected table is displayed below:
Table 1 Inherent isomerization issue in AlCl3-promoted Friedel–Crafts acylationa

image file: c9qo90072a-u1.tif
Entry Temp (°C) Time (min) Concn (M) Conv. (%) Select. (E[thin space (1/6-em)]:[thin space (1/6-em)]Z)b Yieldc (%)
a Reaction using 1a (0.5 mmol), 2a (0.5 mmol), AlCl3 (0.55 mmol) in CH2Cl2. b Determined by 1H NMR of the crude mixture. c Isolated yields of (E)-3a after column chromatography.
1 0 5 0.1 31 4[thin space (1/6-em)]:[thin space (1/6-em)]1 22
2 0 10 0.1 53 2.5[thin space (1/6-em)]:[thin space (1/6-em)]1 35
3 0 20 0.1 63 1.7[thin space (1/6-em)]:[thin space (1/6-em)]1 38
4 0 40 0.1 82 1[thin space (1/6-em)]:[thin space (1/6-em)]1 41
5 0 5 1 73 1.2[thin space (1/6-em)]:[thin space (1/6-em)]1 37
6 0 10 1 80 1[thin space (1/6-em)]:[thin space (1/6-em)]1 39
7 0 20 1 88 1[thin space (1/6-em)]:[thin space (1/6-em)]1.5 35
8 0 40 1 91 1[thin space (1/6-em)]:[thin space (1/6-em)]2 29
9 23 5 0.1 46 2.5[thin space (1/6-em)]:[thin space (1/6-em)]1 30
10 23 10 0.1 54 1.5[thin space (1/6-em)]:[thin space (1/6-em)]1 31
11 23 20 0.1 66 1[thin space (1/6-em)]:[thin space (1/6-em)]1 33
12 23 40 0.1 88 1[thin space (1/6-em)]:[thin space (1/6-em)]2 27

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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