Yu-Chun Cheng, Cong-Shuai Wang, Tian-Zhen Li, Feng Gao, Yinchun Jiao and Feng Shi
Org. Biomol. Chem., 2019,17, 6662-6670
DOI:
10.1039/C9OB00918C,
Paper
The first [4 + 2] cyclizations of para-quinone methide derivatives with isocyanates have been established under the catalysis of Brønsted acids or Brønsted bases, which efficiently constructed benzoxazin-2-one frameworks in generally high yields (up to 95%). This reaction will not only enrich the research contents of para-quinone methide-involved cyclization reactions but also provide a useful method for constructing biologically important benzoxazin-2-one frameworks.