Jinwei Yuan, Shuainan Liu, Yongmei Xiao, Pu Mao, Liangru Yang and Lingbo Qu
Org. Biomol. Chem., 2019,17, 876-884
DOI:
10.1039/C8OB03061H,
Paper
A novel and convenient palladium-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with acetonitrile was developed to synthesize 3-amidated quinoxalin-2(1H)-ones. A series of 3-acetamino quinoxalin-2(1H)-one derivatives were constructed with good to excellent yields. This methodology provided a practical approach to various 3-acetamino quinoxalin-2(1H)-ones from the readily available starting material acetonitrile.
