Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells

Aijun Li; Yu Fan; Xueyan Cao; Liang Chen; Le Wang; Carla S. Alves; Serge Mignani; Jean-Pierre Majoral; Helena Tomás; Xiangyang Shi

doi:10.1039/C9NR06410A

Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells†

Aijun Li,‡^a Yu Fan,‡^a Xueyan Cao,

‡^a Liang Chen,^ab Le Wang,

^c Carla S. Alves,^d Serge Mignani,^de Jean-Pierre Majoral,

*^b Helena Tomás

*^d and Xiangyang Shi

*^ad

Author affiliations

* Corresponding authors

^a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
E-mail: xshi@dhu.edu.cn

^b Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France
E-mail: jean-pierre.majoral@lcc-toulouse.fr

^c College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, People's Republic of China

^d CQM-Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal
E-mail: lenat@uma.pt

^e Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, 75006 Paris, France

Abstract

A novel bioactive macromolecule based on morpholino-functionalized phosphorus dendrimers (generation 2, G2-Mor⁺) was developed for osteogenic differentiation of mesenchymal stem cells (MSCs). Interestingly, through in vitro tests, it was shown that G2-Mor⁺ dendrimer can strongly promote the transformation of MSCs into osteoblasts, which implies the potential application of phosphorus dendrimers in bone regeneration for precision regenerative medicine.

Nanoscale

Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells†

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