Shortwave infrared fluorescence in vivo imaging of nerves for minimizing the risk of intraoperative nerve injury

Heng Xu; Jun Chen; Zhujun Feng; Kan Fu; Yusen Qiao; Zheng Zhang; Wenjin Wang; Yueming Wang; Jian Zhang; Aurelia Trisliana Perdanasari; Matthew M. Hanasono; L. Scott Levin; Xing Yang; Yuefeng Hao; Yunxia Li; Yan Wo; Yixin Zhang

doi:10.1039/C9NR06066A

Shortwave infrared fluorescence in vivo imaging of nerves for minimizing the risk of intraoperative nerve injury†

Heng Xu,‡^a Jun Chen,

‡*^b Zhujun Feng,‡^c Kan Fu,^d Yusen Qiao,^e Zheng Zhang,^a Wenjin Wang,^a Yueming Wang,^f Jian Zhang,^b Aurelia Trisliana Perdanasari,^g Matthew M. Hanasono,^h L. Scott Levin,ⁱ Xing Yang,

^j Yuefeng Hao,*^j Yunxia Li,^b Yan Wo*^c and Yixin Zhang*^ak

Author affiliations

* Corresponding authors

^a Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
E-mail: zhangyixin6688@hotmail.com

^b Department of Orthopedic Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China
E-mail: biochenjun@fudan.edu.cn, woyansh@163.com

^c Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

^d Silicon Products Group, Applied Materials Inc., Sunnyvale, CA, USA

^e P. Roy and Diana T. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA

^f Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China

^g Division of Plastic Surgery Baylor College of Medicine, Houston, TX, USA

^h Department of Plastic Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA

ⁱ Division of Plastic Surgery, Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

^j Department of orthopedics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215500, Jiangsu, China
E-mail: 13913109339@163.com

^k National Engineering Research Center for Nanotechnology, Shanghai, China

Abstract

Here, we present a novel nerve specific imaging agent for preventing intraoperative nerve injuries based on SWIR QD-based in vivo imaging, which not only provides real-time and long-time SWIR images to intraoperatively identify nerves but can also markedly minimize the risk of iatrogenic nerve injuries during surgeries.

Nanoscale

Shortwave infrared fluorescence in vivo imaging of nerves for minimizing the risk of intraoperative nerve injury†

Abstract

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Shortwave infrared fluorescence in vivo imaging of nerves for minimizing the risk of intraoperative nerve injury

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