Issue 8, 2019

Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

Abstract

Here, Cu-TCPP MOF nanodots (denoted as CTMDs) were fabricated; they could functionally and structurally mimic the antioxidant superoxide diamutase (SOD) for alleviating endotoxemia with the ability of renal enrichment and clearance. CTMDs featured with a biomimetic size, a similar Cu active site coordination environment to that of natural SOD and ordered channels similar to substrate channels exhibited the highest SOD-like activity among other nanozymes. Together with the GPx-like activity, the bio-inspired CTMDs could protect cell components in vitro as well as reduce the systemic inflammation and mortality in an endotoxemia model in vivo.

Graphical abstract: Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2019
Accepted
24 Apr 2019
First published
25 Apr 2019

Mater. Horiz., 2019,6, 1682-1687

Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

L. Zhang, Y. Zhang, Z. Wang, F. Cao, Y. Sang, K. Dong, F. Pu, J. Ren and X. Qu, Mater. Horiz., 2019, 6, 1682 DOI: 10.1039/C9MH00339H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements