Issue 9, 2019

Emerging modes-of-action in drug discovery

Abstract

An increasing focus on complex biology to cure diseases rather than merely treat symptoms has transformed how drug discovery can be approached. Instead of activating or blocking protein function, a growing repertoire of drug modalities can be leveraged or engineered to hijack cellular processes, such as translational regulation or degradation mechanisms. Drug hunters can therefore access a wider arsenal of modes-of-action to modulate biological processes and this review summarises these emerging strategies by highlighting the most representative examples of these approaches.

Graphical abstract: Emerging modes-of-action in drug discovery

Article information

Article type
Review Article
Submitted
08 May 2019
Accepted
21 Jun 2019
First published
25 Jun 2019

Med. Chem. Commun., 2019,10, 1550-1568

Emerging modes-of-action in drug discovery

E. Valeur, F. Narjes, C. Ottmann and A. T. Plowright, Med. Chem. Commun., 2019, 10, 1550 DOI: 10.1039/C9MD00263D

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