Issue 2, 2019

α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

Abstract

Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacological therapy. Our aim was to investigate the potential of α-ionone, a naturally occurring flavoring agent, in preventing muscle atrophy and to delineate the mechanisms involved. We found that α-ionone not only stimulated myogenesis but also attenuated palmitic-acid-induced atrophy of cultured skeletal myotubes, as evidenced by an increased myotube diameter and length, fusion index, and cellular protein content. These beneficial actions of α-ionone were abrogated by cAMP inhibitor. The antiatrophic effects of α-ionone on cultured myotubes were confirmed in a corresponding mouse model. The skeletal muscle mass, muscle protein content, myofiber diameter, and muscle strength were greater in α-ionone-treated mice than in untreated animals fed high-fat diet. Furthermore, α-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet. Thus, α-ionone is a promising agent that may enhance skeletal muscle mass and strength.

Graphical abstract: α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

Supplementary files

Article information

Article type
Paper
Submitted
12 Oct 2018
Accepted
03 Feb 2019
First published
05 Feb 2019

Food Funct., 2019,10, 1167-1178

α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice via activation of cAMP signaling

T. Tong, M. Kim and T. Park, Food Funct., 2019, 10, 1167 DOI: 10.1039/C8FO01992D

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