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Why is high persistence alone a major cause of concern?

Ian T. Cousinsa, Carla A. Ngb, Zhanyun Wangc and Martin Scheringer*d
aDepartment of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-10691 Stockholm, Sweden
bDepartment of Civil & Environmental Engineering, University of Pittsburgh, 3700 O'Hara St, Pittsburgh, PA 15261, USA
cChair of Ecological Systems Design, Institute of Environmental Engineering, ETH Zürich, 8093 Zürich, Switzerland
dInstitute of Biogeochemistry and Pollutant Dynamics, ETH Zürich, Universitätstr. 16, 8092 Zürich, Switzerland. E-mail:

Received 5th November 2018 , Accepted 28th March 2019

First published on 29th March 2019

Persistence is a hazard criterion for chemicals enshrined in chemical regulation worldwide. In this paper, we argue that the higher the persistence of a chemical, the greater the emphasis that it should be given in chemicals assessment and decision making. We provide case studies for three classes of highly persistent chemicals (chlorofluorocarbons, polychlorinated biphenyls, and per- and polyfluoroalkyl substances) to exemplify problems unique to highly persistent chemicals, despite their otherwise diverse properties. Many well-known historical chemical pollution problems were the result of the release of highly persistent chemicals. Using evaluative modeling calculations, we demonstrate that if a chemical is highly persistent, its continuous release will lead to continuously increasing contamination irrespective of the chemical's physical–chemical properties. We argue that these increasing concentrations will result in increasing probabilities of the occurrence of known and unknown effects and that, once adverse effects are identified, it will take decades, centuries or even longer to reverse contamination and therefore effects. Based on our findings we propose that high persistence alone should be established as a sufficient basis for regulation of a chemical, which we term the “P-sufficient approach”. We argue that regulation on high persistence alone is not over-precautionary given the historical and ongoing problems that persistent chemicals have caused. Regulation of highly persistent chemicals, for example by restriction of emissions, would not only be precautionary, but would serve to prevent poorly reversible future impacts.

Environmental significance

Chemicals that are resistant to degradation in the environment are called persistent. High persistence (degradation half-lives of six months or more) has important implications for the behavior of chemicals in the environment. Persistent chemicals are distributed widely, often globally, and reach (much) higher concentrations than short-lived chemicals emitted at the same rate. We illustrate these features of highly persistent chemicals using a unit-world environmental fate model. Over the last decades, highly persistent chemicals such as polychlorinated biphenyls have caused serious impacts on the environment and human health. We argue that high persistence should be given particular emphasis in chemicals assessment and management and that highly persistent chemicals should be regulated on the basis of their persistence alone (P-sufficient approach).

1 Introduction

The persistence of organic chemicals has been an important element of chemical hazard assessment for over 40 years.1–4 High persistence indicates the potential for long-lasting environmental and human exposure to a chemical that is difficult to control and reverse.5–7 The importance of persistence is reflected by the persistence (P) criterion in the PBT (persistence, bioaccumulation potential, toxicity) assessment schemes used under the Stockholm Convention on Persistent Organic Pollutants and in an increasing number of jurisdictions such as Australia, Canada, the EU, Japan, South Korea and the US, and by the “very persistent” (vP) criterion under the EU chemicals regulation, REACH. A review of the historical development of international persistence criteria is provided by Matthies and Beulke (2017).8 Here we suggest that the higher the persistence of a chemical, the greater the emphasis that it should be given in chemicals assessment and decision-making. Specifically, the aim of this work is to provide a transparent and conclusive reasoning why, from a certain point on, the persistence of a chemical indicates such a high level of concern that it should be given strong priority in the assessment and management of such a chemical.

The focus of this work is on the persistence of organic chemicals,9 which is generally quantified in terms of degradation half-lives in individual environmental media (“single-media half-lives”).8,10 Not covered are synthetic polymers; stable (“persistent”) inorganic substances such as water, nitrogen (N2), salts, mineral substances (e.g. concrete and sand), and metals such as anthropogenically mobilized mercury, cadmium and lead. Although synthetic polymers are not explicitly included, some challenges associated with synthetic polymers, which are poorly degradable by their very nature, are addressed in the Discussion section.

By “high persistence” we mean that a chemical has at least one degradation half-life exceeding, for example, 6 months. Importantly, this value is just indicative and not meant as a proposal for a regulatory cutoff value (regulatory implementation of the approach proposed here will be a separate step).

The particular importance of the persistence of chemicals was already pointed out by Stephenson (1977)1 more than 40 years ago:

“On the face of it there appears little reason to be concerned about a material which, even though present in the environment, it not causing any detectable damage. On the other hand, persistent materials, because of this property, will accumulate in the environment for as long as they are released. Since the environment is not effective at cleansing itself of these materials, they will remain for indefinite periods which were not recognized at the time of their original release. The problem could become entirely out of control and it would be extremely difficult if not impossible to do anything about it. Materials which are strongly persistent can accumulate to rather high levels in the environment and effects which would not otherwise be important could become so”.

Since then, this point has been reiterated by several authors every 5–10 years.2,3,5,7,10–14 Our final conclusion from all of these analyses is that there may be chemicals whose persistence is so high that it is sufficient alone as a basis for the regulation of these chemicals.

Here we first present conceptual arguments that highlight the meaning of the persistence of chemicals for the occurrence of exposure and, importantly, also risks. We then use results from a multi-compartment environmental fate model to further illustrate these arguments, and finally draw conclusions for the assessment and management of highly persistent chemicals and discuss, also in the context of the precautionary principle, the “P-sufficient” approach that we introduce here.

The P-sufficient approach is intended to complement established methods of chemical risk assessment. It starts from the well-established insight that for PBT chemicals a risk assessment would be fraught with too much uncertainty and that, therefore, these chemicals should be assessed and managed on the basis of their PBT properties.15,16 Here we maintain that of these three properties P is of particular importance and that all chemicals that show a high persistence should be assessed and managed on the basis of their high persistence alone, irrespective of their B and T properties. This approach applies only to a small subset of organic chemicals on the market and does not have any implications for the majority of chemicals, which are not highly persistent and can be managed on the basis of existing chemical regulatory approaches.

2 Why persistence matters and what it means

Persistent chemicals are at the center of many of the most serious cases of environmental contamination in the last 50 years. Examples are polychlorinated biphenyls (PCBs),13,17 chlorofluorocarbons (CFCs),18,19 and per- and polyfluoroalkyl substances (PFASs).20 These cases have been investigated in much detail; Table 1 provides an overview of the chemicals' persistence, production history and the major issues that follow from their persistence. Importantly, the adverse effects caused by persistent chemicals are not limited to health effects in humans and wildlife, but also include physical and chemical effects such as ozone depletion and global warming.
Table 1 Overview of the persistence, production history, and major issues associated with three well-known classes of persistent chemicals. CFCs = chlorofluorocarbons; PCBs = polychlorinated biphenyls; PFASs = per- and polyfluoroalkyl substances; PFAAs = perfluoroalkyl acids; PFOA = perfluorooctanoic acid
Persistence Many decades to a century or more in the stratosphere21 Years to decades22 in terrestrial and aquatic environments All PFASs are, or ultimately transform into, stable substances, often PFAAs. PFAAs degrade slowly in the air23 and negligibly in other media.24–26
Production history Since the late 1930s[thin space (1/6-em)]27 Since 1929[thin space (1/6-em)]28 Since the late 1940s[thin space (1/6-em)]29
First report(s) of presence Mid-1960s early 1970s after invention of the electron capture detector30–32 Late 1960s33,34 Organofluorine fraction discovered in human blood in 1968[thin space (1/6-em)]35 and in 1976[thin space (1/6-em)]36 PFOA tentatively identified using NMR.
Start of large-scale investigation 1970s following the discovery of their depletion of stratospheric ozone37 1970s following the first reports of their presence 2000s after discovery of widespread presence of PFAAs in wildlife38 and human blood39
[thin space (1/6-em)]
Major issues associated with the persistence of the chemicals
Long-range transport/previously unexpected exposure The atmospheric lifetime of CFCs is long enough to reach, and be persistent in, the stratosphere32 PCBs are globally transported40 and present everywhere in the global environment, even in regions far away from sources (e.g. Antarctica,41 deep oceans42 and Arctic biota43) PFASs are globally distributed (e.g. in oceans44 and soils,45 wildlife46 and human blood47) including at poles (e.g. Antarctic48). Short-chain PFAAs are very mobile and can easily pass through drinking water treatment facilities49
Delayed identification of unexpected effects More than 40 years after their large-scale production began, CFCs were shown to be depleters of stratospheric ozone37 and later also found to be potent greenhouse gases50 In the late 1960s, it was shown that PCBs bioaccumulate in Baltic food webs42 and later reproductive effects on seals51 and white-tailed eagles52 were observed. In the 1980s, it emerged that PCBs could affect unborn children53–55 Exposure to low doses of PFAAs at an early stage of life produces effects not captured by current regulatory testing guidelines (e.g., developmental and immuno-toxicity, endocrine disruption, etc.56). Consideration of immunotoxicity in health guidelines has reduced the assumed safe levels by orders of magnitude57
Effectiveness of risk assessments In 1973, J. Lovelock concluded “that the presence of these compounds constitutes no conceivable hazard”.32 Stratospheric ozone depletion was an unknown effect at that time Risk assessments have been continually refined (health guideline values revised downwards) from the 1920s to the present day as new information on effects emerged5 Risk assessments do not reflect the long-term and irreversible exposure to PFASs,7,20 many PFASs are not considered in risk assessment, and mixture toxicity and non-standard toxicity tests are often neglected. One can therefore expect continual refinement of risk assessments20
Effectiveness of regulatory actions International agreement was reached under the Montreal Protocol, which entered into force in 1987. The Montreal Protocol only called for a reduction in emissions of certain damaging CFCs, with later amendments agreeing to their phase-out by 2000. Despite this phase-out, it takes decades for the ozone layer to recover58 Regulatory action began in the late 1970s in some western countries when there was a high level of proof of effects associated with PCBs, but manufacture and use continued elsewhere.39 Despite their eventual global phase-out, PCBs are still present in many applications and will continue to be major contaminants for decades to come. Levels in soils,59 sediments60 and biota61 decline especially slowly Regulatory action can eliminate point source emissions. However, it has no influence on what has already been emitted. Environmental redistribution of PFASs will continue for decades, and background levels will keep increasing.62 For example, PFOS levels in humans started to decrease after actions by 3M in 2000–2002, but there are no clear trends for environmental and wildlife levels yet63
Technical implications for remediation Stopping emissions was the only way to reduce levels in the troposphere and thus stratosphere, and this was achieved through international treaties PCBs can be found in contaminated soils and sediments. The most frequent remediation solutions adopted have been “dig and dump” and “dig and incinerate”, but there are currently new methods emerging64 It is energy-intensive to break the C–F bond to mineralize PFASs. The most effective method for large-scale treatment is through incineration at high temperatures; new advanced mineralization methods are being developed.65 Short-chain PFASs are too mobile to be concentrated, causing additional challenges in remediation65
Financial implications for remediation CFC replacements were quickly identified (but often have high global warming potential), but some economies were less able to cover the costs of switching to these alternatives.58 Average destruction costs are estimated to range from $4 to over $6 per kg (for concentrated refrigerant or blowing agent)66 The costs of legacy PCB contamination in the European Union have been estimated to be as high as 75.3 billion Euros between 1971 and 2018[thin space (1/6-em)]13,20 High energy demand means it is very costly to safely dispose of contaminated products and remediate contaminated sites even if technically feasible. Costs of remediation are currently uncertain. The U.S. Air Force estimates that it will cost them $2 billion to clean up PFAS-contaminated water66

The cases in Table 1 and others (e.g. PCDD/Fs,67–69 brominated flame retardants,70–72 organochlorine pesticides73) show that, empirically, the particular concerns caused by highly persistent chemicals have been documented in much detail. Conceptually, the essence of why high persistence is of outstanding importance in chemicals assessment is perhaps less obvious and worth clarifying here. The concern about a chemical in the environment is, of course, related to unwanted effects (of any kind, e.g. toxic effects on wildlife or humans, global warming, ozone depletion, see Table 1) that the chemical may cause. However, as has been learned from many cases in chemical risk assessment (e.g. immunotoxicity of PFASs,57 endocrine disrupting effects,74 effects of neonicotinoid pesticides75), adverse effects are difficult to predict and the scientific knowledge about effects will always remain uncertain and, importantly, incomplete. This is because the number of possible effects is infinite and it is epistemologically impossible to identify them all. This means that unexpected effects may always occur.

If unexpected effects are caused by a short-lived chemical, it is possible to rapidly cease environmental contamination by restricting or banning its use, which then also means that no additional effects will be caused by that chemical. This is why short-lived chemicals that are released to the environment at high rates should not be called “pseudo-persistent” or “semi-persistent”. In such a case, high levels in the environment are observed, but they are solely caused by continuous and high emissions, not by any type of persistence of the chemical.

In contrast, in the case of highly persistent chemicals, it is not possible to cease environmental contamination within a reasonable time frame by simply restricting or banning their use. Environmental contamination by highly persistent chemicals – and the effects related to this contamination – will continue for years to decades. This poor reversibility of contamination is because highly persistent chemicals are, by definition, difficult to degrade. This implies that highly persistent chemicals will require high inputs of energy to remove them from the environment, either directly for the destruction of their stable chemical bonds (e.g. incineration) or through methods to remove them from the environment that require substantial energy inputs to drive their separation from contaminated media (e.g. pump and treat: pumping water out of groundwater aquifers and subsequent treatment). Examples of the high costs associated with remediation of highly persistent chemicals are provided in Table 1. Importantly, removal or remediation is only feasible for contamination hotspots, but not for the majority of the environment such as the world's oceans.

It is logically incorrect to say that persistence merely indicates the presence of a chemical in the environment. Persistence indicates an impactful causal relationship that extends into the future: persistent chemicals that are present now will also be present to a certain extent after a considerable number of years (e.g., 25% after 10 years if the degradation half-life is 5 years), and this fact is known already now with certainty. They have the potential to undergo long-range transport in the environment, and then an increasing number of organisms in many ecosystems as well as humans will be exposed, including ones for which this was unexpected such as the Mariana Trench in the case of PCBs.42 This includes not only chemicals that are volatile and soluble in water, but also low-volatility chemicals with very high octanol–water partition coefficients (KOW) and octanol–air partition coefficients (KOA), such as deca-BDE and heavy PCBs.

Furthermore, high persistence indicates that certain thresholds for causing (often unexpected) effects will be exceeded, and this can also be predicted with high reliability. If a substance is persistent, and if emissions continue at a constant rate or increase (because the substance is of technical and economic interest), the substance will attain higher and higher concentrations in the environment. In this case, the risk quotient (i.e. PEC/PNEC ratio) also increases continuously up to the point that the concentration may exceed no-effect thresholds (see examples given in Section 3, below). And even if persistent chemicals are present at low concentrations and do not (yet) exceed effect thresholds, they will still be present when, in the future, other chemicals will be emitted so that there will be co-exposure that may cause mixture effects.

In summary, the main concerns with highly persistent chemicals are:

(1) The continuous release of highly persistent chemicals will lead to widespread, long-lasting, and increasing contamination.

(2) Increasing concentrations will result in increasing probabilities that known and unknown effects occur, be it by a single chemical and/or in a mixture with other substances.

(3) Once adverse effects are identified, it will be technically challenging, energy intensive, and thus costly, to reverse the chemical contamination and therefore the effects. These measures are limited to contamination hotspots, whereas, for most of the environment, no remediation or clean-up will be possible.

Therefore, it is not an unsubstantiated concern about the mere presence of a chemical, but it is the much higher likelihood for particularly serious (widespread, long-lasting) adverse effects associated with highly persistent chemicals – effects that have become manifest many times as the historical examples show – that confers particular importance to persistence as a hazard indicator for triggering management actions. In conclusion, concerns about a chemical are always related to effects, but for highly persistent chemicals, it should not be required that these effects are represented explicitly in the hazard assessment scheme. The hazard assessment of these chemicals should be based solely on their high persistence as a placeholder or proxy for effects.

3 Mass-balance modeling

Here we illustrate the implications of high persistence for the levels and time trends of chemicals in the environment using a simple multimedia environmental fate model for four example chemicals. The purpose of the modeling work is to illustrate and compare the environmental behavior of highly persistent vs. short-lived chemicals, but not to reflect any particular setting. No modeling of this type is needed in the evaluation of chemicals for persistence. The model is a so-called unit-world model76 with three compartments: the global troposphere (height 6000 m, volume 3.06 × 1018 m3), the global surface ocean water (depth 100 m, volume 3.62 × 1016 m3), and the global surface soil (depth 0.1 m, volume 1.48 × 1013 m3). In each compartment, a first-order degradation process takes place; in addition, there are three non-degradative losses: diffusion to the stratosphere, settling to deep ocean water, and burial in deep soil. These non-degradative losses from the model system are not true sinks, but reflect transfer of chemical to parts of the environment not included in this particular model.

The model parameters for transfer processes between different compartments, such as the rain rate or soil runoff rate, are the same as in many other environmental fate models and are listed in Table 7.2 of the book by Mackay (2001).77

In total, we modeled four hypothetical chemicals that differ in their degradation half-lives and KOW values, see Table 2. Here we use the KOW to describe the phase partitioning of the example chemicals. Although PFAAs, as one important class of highly persistent chemicals, are dissociated, i.e. present as anions, at environmental pH, they partition to organic matter similar to hydrophobic organic substances with a log[thin space (1/6-em)]KOW of around two.78 For all three compartments, the same degradation half-lives of 2 d (chemicals A and C) and 2000 d (chemicals B and D) were assumed. A half-life of 2000 d or 5.5 years is long, but not excessively high. PFASs, for example most PFAAs, can have much longer half-lives. If PFAAs degrade, they do it so slowly that it is not observable and their half-lives could be on the order of decades, centuries or even greater.79

Table 2 Chemical property data of the four example chemicals
Property Chemical A Chemical B Chemical C Chemical D
log[thin space (1/6-em)]KAW −1 −1 −1 −1
log[thin space (1/6-em)]KOW 2 2 8 8
t1/2 (d) 2 2000 2 2000

In a first emission scenario, we assumed the same constant emission rate to air (100 mol h−1) for each chemical and calculated the concentrations in air, water and soil at steady-state and in a dynamic scenario where the initial concentrations in all media are equal to zero. The absolute value of the emission rate is not relevant here because we compare results of the chemicals relative to one another. The results would be the same with any emission rate.

In reality, emissions may be constant or even increasing as long as a chemical is extensively used in open applications, often over many years or decades, and then decrease in a later stage.62 To capture this situation, we ran a second emission scenario with emissions increasing linearly for 10 years and then decreasing linearly for another 10 years. This is still an idealized scenario; for an example of a realistic emission history and the ensuing environmental distribution of a chemical, see, for example, Boucher et al. (2019).80 In this second scenario, we compare chemicals C and D.

The main model results are summarized in Table 3; several features of the concentration–time curves of the different chemicals are illustrated in Fig. 1 and 2. For each chemical, the results in Table 3 include the total amount present in the model system; concentrations and fractions in air, water and soil; the overall persistence; the degradation losses in comparison to non-degradation losses, and the time-to-steady-state, defined as the time at which the total amount of chemical in the system has reached 99.9% of the amount at steady-state. The overall persistence, τ, is calculated as the total amount of chemical at steady-state (in mol) divided by the degradation losses (in mol h−1). It is related to the single-media half-lives, t1/2,i, by eqn (1):

image file: c8em00515j-t1.tif(1)
where the fi are the fractions of the chemical in the different media. If the single-media half-lives are the same (the case here), τ is equal to t1/2/ln[thin space (1/6-em)]2.

Table 3 Main model results for the scenario with constant emissions. Regular font: results from steady-state model. Bold: results from dynamic model
Quantity Chemical A Chemical B Chemical C Chemical D
Total inventory (mol) 6.92 × 103 4.14 × 106 6.94 × 103 3.69 × 106
cA (mol m−3) 2.26 × 10−15 1.22 × 10−12 2.25 × 10−15 3.06 × 10−13
cW (mol m−3) 4.56 × 10−16 1.16 × 10−11 5.70 × 10−16 2.80 × 10−12
cS (mol m−3) 1.86 × 10−14 1.43 × 10−11 1.50 × 10−12 1.79 × 10−7
Fraction in air, fa 1.0 0.9 0.99 0.25
Fraction in water, fw 0 0.1 0.00 0.03
Fraction in soil, fs 0 0 0.01 0.72
Overall persistence, τ (d) 2.88 2.89 × 103 2.88 2.89 × 103
Sum degradation losses (mol h−1) 99.9 59.8 99.9 53.2
Sum non-degradation losses (mol h−1) 0.1 40.2 0.1 46.8
Time to steady-state 20 d 33 years 20 d 48.5 years

image file: c8em00515j-f1.tif
Fig. 1 Concentrations of different model chemicals as a function of time in the scenario with constant emissions (chemical B not shown). (i) Chemical A with a t1/2 = 2 days and log[thin space (1/6-em)]KOW = 2 is present in all three media in appreciable amounts and reaches its steady-state after approximately 0.05 year. (ii) Chemical C with t1/2 = 2 days, but a log[thin space (1/6-em)]KOW of 8, reaches its steady-state also after less than 0.1 year, but is mostly present in the soil. (iii) Chemical D with t1/2 = 2000 days and log[thin space (1/6-em)]KOW = 8 reaches its steady-state after approximately 33 years and is mostly present in the soil. (iv) Comparison of the concentrations in soil of chemicals C (short half-life) and D (long half-life). After 10 years, the concentration of chemical D is 84[thin space (1/6-em)]000 times greater than that of chemical C and is still building up, see panel (iii); their emission rates are the same.

Important observations from the scenario with constant emissions are as follows:

An increase in the degradation half-life by a factor of 1000 (from 2 d to 2000 d, chemicals A vs. B, see Table 2, and chemicals C vs. D, see Fig. 1, panel (iv)) leads to an increase in the time to steady-state by a factor of 600–880 (from 20 d to 33–48.5 years). This increase is lower than a factor of 1000 because of the advective losses. These do not scale with the degradation half-lives and, therefore, become increasingly important if the degradation half-life is longer (see Table 3, degradation losses vs. non-degradation losses). Similarly, the increase in the total inventory of chemical in the model system is only around a factor of 550 to 600 because of the increasing effect of the non-degradation losses. Next, the steady-state concentrations in air, water and soil of the highly persistent chemicals, B and D (half-life 2000 d), are higher by factors of 136 to 1.19 × 105, compared to the short-lived chemicals. Here it is the influence of the non-degradation losses in combination with different partitioning because of different KOW values that explains why they differ from 1000. Chemical D, for example, is rapidly deposited from the air to soil and water with settling particles and accumulates in the soil, which is caused by its high KOW in combination with the high half-life. Accordingly, the concentration in air of chemical D increases only by a factor of 136 compared to chemical C, but its concentration in soil increases by a factor of 1.19 × 105, which is much more than the 1000-fold increase in the half-lives.

An increase in log[thin space (1/6-em)]KOW by 6 log units leads to a shift of the chemical from air and water to soil (see panels (i) and (ii) in Fig. 1). However, this does not change the overall persistence because in the examples presented here each chemical has the same degradation half-life in all environmental media. For short-lived chemicals the half-lives often vary markedly between environmental media, but in the case of highly persistent chemicals such as PFASs the half-lives are long in all media and degradation is slower than all phase-partitioning processes. Therefore, in the case of highly persistent chemicals, the partitioning properties (e.g. KOW) are not important for controlling the overall persistence of a chemical in the environment.

In the scenario with dynamic emissions, the concentrations of the short-lived chemical (chemical C) directly follow the time course of the emissions (Fig. 2, panel (i)). This illustrates that it is easily possible to quickly reduce even high concentrations of a short-lived chemical by reducing the emissions. The long-lived chemical (chemical D), in contrast, shows a marked overshoot with increasing concentrations for more than 4 years after the emission peak in year 10 (concentration peak in year 14.5, see Fig. 2, panel (ii)). Moreover, the decreasing concentrations form a long tail that extends for many years after the stop of the emissions in year 20. This type of behavior is also visible in reality for PCBs and other highly persistent chemicals after the stop of major emissions, see overview and references in Table 1.

image file: c8em00515j-f2.tif
Fig. 2 Concentrations of chemicals C (panel (i)) and D (panel (ii)) as function of time in the scenario with dynamic emissions. For both chemicals, emissions start in year 0, increase by 10 mol h−1 every year, peak in year 10 at a value of 100 mol h−1, then decrease by 10 mol h−1 every year, and end in year 20. Note the much higher levels of chemical D compared to chemical C.

PFAAs are a class of chemicals with extremely long degradation half-lives in all media and it is therefore interesting to compare their environmental behavior with our modeling results. A steady-state condition was never reached for PFAAs because production continually increased between 1950 and 2000 until action to reduce emissions was taken. Even if emissions had levelled off at their production peak in the late 1990s, our modeling results imply that environmental levels would have continued to increase for many decades afterwards. Since action to reduce emissions of PFAAs commenced, starting in 2000–2002, there has been no evidence of consistent declines of any PFAA in the environment or biota.63 Perfluoroalkyl carboxylic acids with nine or more carbons continue to increase in human blood even after measures to reduce their emissions were introduced.63

4 Discussion and recommendations

Model-derived findings

The model results presented above illustrate the important general implications of high persistence: the higher the persistence of a chemical, the longer the time-to-steady state, the higher the steady-state concentrations, and the greater the overshoot and long-lasting contamination tail after the end of the emissions. Another important finding from the model results is that the KOW does not modify these general implications of high persistence. The KOW does modify the specific properties and environmental distribution of a chemical, but if the degradation half-lives are long in all media, the persistence-related concerns (high time-to-steady state, overshoot, etc.) are present irrespective of the values of the partition coefficients. This has an important implication: a high KOW is generally related to a high bioaccumulation factor,81 and a high bioaccumulation factor is an additional source of concern, but the fundamental concerns related to high persistence are independent of any bioaccumulation (“B”) properties of a chemical. B is not a useful criterion for protecting against poorly reversible effects because the residence time of highly persistent chemicals in the environment is often much greater than their residence time in humans and biota, which means that levels in organisms will be poorly reversible regardless of the magnitude of B.7 The irrelevance of environmental partitioning with regard to regulation of highly persistent chemicals is reflected on the regulatory side by two regulatory schemes that both focus on persistent chemicals, in one case with high KOW (Stockholm Convention on POPs, KOW cutoff of log[thin space (1/6-em)]KOW > 5),82 and in one case with low KOW (the proposed scheme for persistent, mobile and toxic (PMT) chemicals with a cutoff of log[thin space (1/6-em)]KOW < 4).9,83,84

Policy implications of the findings

Based on the findings presented above, our general proposal is that, in addition to existing chemical assessment schemes, high persistence should be established as a sufficient basis for regulation of a chemical. We call this the “P-sufficient” approach (a similar reasoning supporting the P-sufficient approach has been presented by Goldenman et al.10). Current chemical assessment schemes place special emphasis on persistent chemicals only if other hazardous properties, such as bioaccumulation potential and toxicity, are also present, whereas high persistence as such is not relevant in chemicals assessment. For example, under REACH the identification of a substance as PBT or vPvB (very persistent and very bioaccumulative) automatically requires the registrant to carry out an estimate of emissions, to identify and implement measures to minimize emissions, to indicate in the safety data sheet (SDS) that the substance is PBT/vPvB, and to communicate measures for minimizing emissions to downstream users via the SDS. However, if a chemical is identified as P or vP, but neither PBT nor vPvB, there is no requirement to estimate and mitigate emissions nor any requirement to consider future continuing emissions in the risk assessment. This is a gap in the current European chemical assessment and management schemes, given that concentrations in the environment and, thereby, also PEC/PNEC ratios keep increasing for a long time for highly persistent chemicals if emissions continue. As far as we know, these deficiencies exist in all international chemical regulation schemes because high persistence in itself is not used as a trigger for regulation in any jurisdiction.

The P-sufficient approach, in contrast, means that high persistence is sufficient for a chemical to be flagged for subsequent management actions. For example, under REACH, the vP criteria could be used for this purpose.10 If a chemical exceeds the vP criteria, the P-sufficient approach would imply that this is sufficient to require estimation (and minimization) of emissions as occurs currently for PBT and vPvB chemicals. Furthermore, the implication of vP properties could be that the chemical is listed as a Substance of Very High Concern (SVHC) without any consideration of its other properties (i.e. B and T in the case of PBT, or vB in the case of vPvB). Here the reference to the vP criteria under REACH is merely a suggestion for how the P-sufficient approach may be implemented. The actual cutoff value(s) for identifying highly persistent chemicals remain to be defined in a subsequent step.

When high persistence is identified for a chemical, the uses of this chemical should be grouped into essential and non-essential uses as a basis for determining management actions.85 Essential uses are uses that are indispensable for the health and/or safety of a certain population of workers, of patients under certain medical treatments, or of other groups, and for which there are no technically and economically feasible alternatives. Non-essential uses, on the other hand, are uses for which there are alternatives or where a substance has no essential technical function in a product and the use is driven only by convenience or market opportunity. These non-essential uses of a substance with high persistence could then be phased out with highest priority, whereas for essential uses measures should be taken that help avoid emissions (no wide-dispersive applications, collection and recycling, etc.). In the longer term, alternatives for these uses should also be developed.

Empirical basis for the proposed “P sufficient” approach

Technically, the P-sufficient approach could be based on the same type of evidence that is currently used for, e.g., the vP assessment under REACH. The substances currently classified as vPvB substances in the EU include, a.o., dechlorane plus, short-chain chlorinated paraffins, UV absorbers, long-chain perfluorocarboxylic acids, PFHxS, musk xylene, and the cyclic volatile methylsiloxanes D4, D5, and D6. A review of the SVHC dossiers of these substances shows that a range of different data has been used for the determination of vP properties. In several cases, simulation tests and field dissipation studies were available (UV absorbers, anthracene oils, short-chain chlorinated paraffins, some of the long-chain perfluorocarboxylic acids). These were often complemented by negative results from tests for ready or inherent biodegradability. In other cases (PFHxS, long-chain PFCAs, D6), read-across from similar chemicals with results from simulation tests for degradation was applied. In one case (deca-BDE), the formation of highly persistent transformation products was used as a reason why the substance was classified as vP. In the same way as for the current vPvB determinations, all these types of data can be used under the P-sufficient approach. If read-across is not possible, simulation tests or field dissipation studies may have to be performed, but this can be done under existing test guidelines. The formation of highly persistent transformation products will also be an important type of evidence, in particular for many PFASs that have reactive endgroups and will form – highly persistent – PFAAs in the environment.

On the one hand, it is advantageous that different types of data can be used for persistence determinations, as outlined above. On the other hand, there is a great need for one particular type of data, namely empirical degradation test results from a large, diverse set of chemicals with intermediate to high persistence. A broader empirical basis of degradation test results will help identify the types and number of highly persistent chemicals and will provide a basis for the development of improved methods for estimating degradation half-lives from the chemical structure.

The P-sufficient approach and the precautionary principle

As pointed out in Section 2, the concern underlying any chemical hazard assessment is about adverse effects. In the context of persistence assessments, this is often expressed in such a way that P seemingly only matters in addition to B and T. This is enshrined in the current PBT assessment schemes, see above, part 2 of this Discussion section, but was already clearly reflected, for example, in the following quote from an internal 3M document from the 1980s,86

“Perhaps the most important conclusion from previous studies is the stability of fluorochemicals. Although stability is one of the most desirable properties fluorochemicals possess for many applications, from an environmental perspective, “stability” connotes “persistence” which can be the cause of concern especially when coupled with other properties. For example, some fluorochemicals have a tendency to accumulate in biological tissues. Moreover, some fluorochemicals have biological activity. This is most seriously demonstrated by the use of some fluorochemicals as pesticides. This is not to say that all fluorochemicals accumulate or that all have biological activity. But taken together, stability, the tendency to bioaccumulate, and biological activity are a potentially troublesome combination”.

In contrast to this approach, the key point of the P-sufficient approach is that this evidence of some type of effect should not be required to be demonstrated explicitly: because the possible effects cannot be predicted with sufficient reliability and remain incompletely known or entirely unknown, high persistence alone should be used as a sufficient indicator that serves as a proxy for adverse effects (see the reasoning provided in Section 2). Often, using a proxy of actual impacts as a basis for decision-making is considered an application of the precautionary principle.5,87,88 The precautionary principle states that, “where there are threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost-effective measures to prevent environmental degradation”.89

A problem with the implementation of the precautionary principle has been that the call for action based on limited evidence is often considered over-cautious. However, the empirical evidence that has accumulated over the last decades shows that it would not be over-cautious to restrict or regulate the use of highly persistent chemicals. When the known cases of highly persistent chemicals are considered, it shows that many of them have caused serious environmental impacts. Accordingly, there is a very high likelihood that additional highly persistent chemicals will also cause some kind of relevant environmental impact. Therefore, regulating highly persistent chemicals on the basis of their persistence alone may well be called an act of prevention, not just of precaution. In other words, it is entirely rational and empirically well founded to take high persistence seriously as a proxy of unwanted environmental impacts and to base preventive action on it.

There are also persistent chemicals that exert relatively low toxicity according to current knowledge, such as trifluoroacetic acid (TFA).90 The point of the P-sufficient approach is exactly that also highly persistent chemicals for which the currently known toxicity is rather low should be flagged and considered for regulation. As outlined above, it is well possible that unwanted effects occur at a large scale if such a chemical enters the environment, is distributed widely, and leads to continuously increasing environmental and human exposure. The evidence available from the last 50 years shows that this is not just a hypothetical possibility, but a highly likely outcome.

Similarly, the P-sufficient approach is also potentially suitable for synthetic polymers, which are (very) poorly degradable by their very nature. Jurisdictions around the world have various ways of defining when a substance is a synthetic polymer based on, for example, molecular weight, number of monomers, percentage impurities etc. We therefore do not provide a specific definition of a synthetic polymer here. Many high-molecular-weight synthetic polymers have traditionally been treated as of low concern under chemical assessment and management schemes due to their low bioavailability. However, as elaborated above, once released, (unexpected) adverse effects by highly persistent chemicals may not only be biological effects, but also be physical or chemical effects. In the case of a subclass of high-molecular-weight synthetic polymers, namely plastics, an increasing number of wildlife mortality by entanglement or ingestion of marine plastic debris has been observed (e.g., Wilcox et al. (2015)[thin space (1/6-em)]91). In addition, plastics may break down into many smaller pieces (i.e., microplastics), which is another issue of emerging concern.92,93 The P-sufficient approach is also in line with the recent call of classifying plastic waste as hazardous94 as well as it being flagged as a planetary boundary threat.95,96

Conflicts of interest

There are no conflicts of interest to declare.


We thank the Global PFAS Science Panel for travel support and helpful discussions.


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