Issue 13, 2019

Late-stage functionalization of BN-heterocycles

Abstract

BN/CC isosterism has emerged as a viable strategy to expand the chemical space of organic molecules. In particular, the application of BN/CC isosterism to arenes has received significant attention due to the vast available chemical space provided by aromatic hydrocarbons. The synthetic efforts directed at assembling novel aromatic BN heterocycles have resulted in the discovery of new properties and functions in a variety of fields including biomedical research, medicinal chemistry, materials science, catalysis, and organic synthesis. This tutorial review specifically covers recent advances in synthetic technologies that functionalize assembled boron–nitrogen (BN) heterocycles and highlights their distinct reactivity and selectivity in comparison to their carbonaceous counterparts. It is intended to serve as a state-of-the-art compendium for readers who are interested in the reaction chemistry of BN heterocycles.

Graphical abstract: Late-stage functionalization of BN-heterocycles

Article information

Article type
Tutorial Review
Submitted
25 Mar 2019
First published
28 May 2019

Chem. Soc. Rev., 2019,48, 3436-3453

Author version available

Late-stage functionalization of BN-heterocycles

C. R. McConnell and S. Liu, Chem. Soc. Rev., 2019, 48, 3436 DOI: 10.1039/C9CS00218A

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