Correction: 4′-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading

Ganesh N. Nawale; Saeed Bahadorikhalili; Pallabi Sengupta; Sandeep Kadekar; Subhrangsu Chatterjee; Oommen P. Varghese

doi:10.1039/C9CC90352F

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DOI: 10.1039/C9CC90352F (Correction) Chem. Commun., 2019, 55, 10028-10028

Correction: 4′-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading

Ganesh N. Nawale ^a, Saeed Bahadorikhalili ^a, Pallabi Sengupta ^b, Sandeep Kadekar ^a, Subhrangsu Chatterjee ^b and Oommen P. Varghese *^a
^aTranslational Chemical Biology Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, Sweden. E-mail: oommen.varghese@kemi.uu.se
^bBiomolecular NMR and Drug Design Laboratory, Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, India

Received 30th July 2019 , Accepted 30th July 2019

First published on 7th August 2019

Abstract

Correction for ‘4′-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading’ by Ganesh N. Nawale et al., Chem. Commun., 2019, 55, 9112–9115.

The authors regret that Table 1 was displayed incorrectly in the original article. The correct version is shown below.

Table 1 The sequences of siRNA duplexes and T_m values

Name	Passenger (5′–3′, above) and guide strand (3′–5′, below)	T _m	ΔT_m^b/mod.
a T _m represents melting temperatures for unmodified and GMU modified siRNA duplexes (bold text indicates modification) in °C. b ΔT_m represents the [T_m (RNA mod.) − T_m (RNA unmod.)]. The T_m values were determined using 1 μM of siRNA in buffer containing 50 mM NaCl, 10 mM Na₂PO₄, pH 7.4. All experiments were triplicated, and the T_m values have reported an average of 3 measurements with the estimated standard deviation.
siRNA1	GGAAGCUGCAGAAAGAUACTT	66.9 ± 0.1
siRNA1	TTCCUUCGACGUCUUUCUAUG	66.9 ± 0.1
siRNA2	GGAAGCUGCAGAAAGAUACTT	67.8 ± 0.3	+0.9
siRNA2	TTCCUUCGACGUCUUUCUAUG	67.8 ± 0.3	+0.9
siRNA3	GGAAGCUGCAGAAAGAUACTT	69.8 ± 0.1	+2.9
siRNA3	TTCCUUCGACGUCUUUCUAUG	69.8 ± 0.1	+2.9
siRNA4	GGAAGCUGCAGAAAGAUACTT	69.5 ± 0.2	+2.6
siRNA4	TTCCUUCGACGUCUUUCUAUG	69.5 ± 0.2	+2.6
siRNA5	GGAAGCUGCAGAAAGAUACTT	69.7 ± 0.3	+2.8
siRNA5	TTCCUUCGACGUCUUUCUAUG	69.7 ± 0.3	+2.8
siRNA6	GGAAGCUGCAGAAAGAUACTT	70.3 ± 0.2	+3.4
siRNA6	TTCCUUCGACGUCUUUCUAUG	70.3 ± 0.2	+3.4

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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