Ti3C2 MXene as a novel substrate provides rapid differentiation and quantitation of glycan isomers with LDI-MS

Yuming Jiang; Jie Sun; Yi Cui; Huihui Liu; Xiaoyong Zhang; Yurong Jiang; Zongxiu Nie

doi:10.1039/C9CC04467A

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Ti₃C₂ MXene as a novel substrate provides rapid differentiation and quantitation of glycan isomers with LDI-MS†

Yuming Jiang,^ab Jie Sun,^ab Yi Cui,

^c Huihui Liu,^ab Xiaoyong Zhang,

^c Yurong Jiang*^d and Zongxiu Nie

*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Key Laboratory for Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China
E-mail: znie@iccas.ac.cn

^b University of CAS, Beijing 100049, China

^c College of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China

^d School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China
E-mail: yrkitty@bit.edu.cn

Abstract

Here we report Ti₃C₂ MXene assisted LDI-LIFT-TOF/TOF for robust differentiation and relative quantitation of glycan isomers that differ in composition, connectivity and configuration. The improved sensitivity and background-free properties of this substrate combined with the special fragment profile produced by LDI-LIFT-TOF/TOF open a new door for nanomaterial assisted glycan structual analysis.

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Article information

DOI: https://doi.org/10.1039/C9CC04467A
Article type: Communication
Submitted: 11 Jun 2019
Accepted: 12 Aug 2019
First published: 13 Aug 2019

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Chem. Commun., 2019,55, 10619-10622

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Ti₃C₂ MXene as a novel substrate provides rapid differentiation and quantitation of glycan isomers with LDI-MS

Y. Jiang, J. Sun, Y. Cui, H. Liu, X. Zhang, Y. Jiang and Z. Nie, Chem. Commun., 2019, 55, 10619 DOI: 10.1039/C9CC04467A

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Chemical Communications