Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy

Weijie Lv; Siyu Chi; Wenqi Feng; Tao Liang; Dan Song; Zhihong Liu

doi:10.1039/C9CC03018B

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Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy†

Weijie Lv,^a Siyu Chi,^a Wenqi Feng,^a Tao Liang,^a Dan Song^a and Zhihong Liu

*^a

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* Corresponding authors

^a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
E-mail: zhhliu@whu.edu.cn

Abstract

A π-extended red absorbing Se-rhodamine (Se-NR) was synthesised and characterized. By masking the amine of Se-NR as an azide, we successfully constructed a bio-orthogonally activatable photosensitizer (Se-NR-Az). Se-NR-Az was not photocytotoxic, but when activated by the Staudinger reaction, photocytotoxicity was restored.

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Article information

DOI: https://doi.org/10.1039/C9CC03018B
Article type: Communication
Submitted: 18 Apr 2019
Accepted: 23 May 2019
First published: 23 May 2019

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Chem. Commun., 2019,55, 7037-7040

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Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy

W. Lv, S. Chi, W. Feng, T. Liang, D. Song and Z. Liu, Chem. Commun., 2019, 55, 7037 DOI: 10.1039/C9CC03018B

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Chemical Communications

Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy†

Abstract

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Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy

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