Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

Weiwu Zeng; Fan Wu; Chaoxing Liu; Yan Yang; Bingyao Wang; Yushu Yuan; Jiaqi Wang; Yuqi Chen; Boshi Fu; Zhiguo Wu; Xiang Zhou

doi:10.1039/C8CC10052G

Small-molecule-based human genome G4 profiling reveals potential gene regulation activity†

Weiwu Zeng,^a Fan Wu,^a Chaoxing Liu,^a Yan Yang,^b Bingyao Wang,^b Yushu Yuan,^a Jiaqi Wang,^a Yuqi Chen,^a Boshi Fu,^a Zhiguo Wu*^c and Xiang Zhou

*^ab

Author affiliations

* Corresponding authors

^a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072, Hubei Province, China

^b Institude of Advanced Studies, Wuhan University, Wuhan 430072, Hubei Province, China
E-mail: xzhou@whu.edu.cn

^c College of Life Sciences, Wuhan University, Wuhan 430072, Hubei Province, China
E-mail: wu.zhiguo@whu.edu.cn

Abstract

Small-molecule-based G4 isolation from genomic DNA has enabled the identification of a total of 51 446 PQSs (potential G-quadruplex sites). Incubating cells with PDP for 3 h to 72 h resulted in the differential expression of a variety of genes, indicating a potential function of G4s in gene regulation.

Chemical Communications

Small-molecule-based human genome G4 profiling reveals potential gene regulation activity†

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