Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2–T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

Jiaomin Lin; Pengyan Xin; Lu An; Yanjun Xu; Cheng Tao; Qiwei Tian; Zhiguo Zhou; Bing Hu; Shiping Yang

doi:10.1039/C8CC08943D

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Fe₃O₄–ZIF-8 assemblies as pH and glutathione responsive T₂–T₁ switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo†

Jiaomin Lin,‡^a Pengyan Xin,‡^a Lu An,^a Yanjun Xu,^b Cheng Tao,^a Qiwei Tian,

^a Zhiguo Zhou,^a Bing Hu*^b and Shiping Yang

*^a

Author affiliations

* Corresponding authors

^a The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China
E-mail: shipingy@shnu.edu.cn

^b Department of Ultrasound in Medicine, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Institute of Ultrasound in Medicine, Shanghai, P. R. China
E-mail: binghu_stan@163.com

Abstract

A small Fe₃O₄ nanoparticles-based T₁ contrast agent was assembled into a pH- and glutathione-responsive T₂–T₁ switching contrast agent, Fe₃O₄–ZIF-8. In vivo T₁-weighted images of mice showed that Fe₃O₄–ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.

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Article information

DOI: https://doi.org/10.1039/C8CC08943D
Article type: Communication
Submitted: 10 Nov 2018
Accepted: 28 Nov 2018
First published: 29 Nov 2018

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Chem. Commun., 2019,55, 478-481

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Fe₃O₄–ZIF-8 assemblies as pH and glutathione responsive T₂–T₁ switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

J. Lin, P. Xin, L. An, Y. Xu, C. Tao, Q. Tian, Z. Zhou, B. Hu and S. Yang, Chem. Commun., 2019, 55, 478 DOI: 10.1039/C8CC08943D

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Chemical Communications