Issue 41, 2018
From the journal:

Organic & Biomolecular Chemistry

Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex†

Biao Wang,a   Yifeng Wang, ORCID logo *a   Yidong Jiang,a   Mingming Chu,a   Suosuo Qi,a   Wanzhen Jua  and  Danqian Xu*a  

* Corresponding authors

a State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: wangyifeng@zjut.edu.cn, chrc@zjut.edu.cn

Abstract

A highly enantioselective fluorination of indanone-2-carboxylates catalyzed by a polystyrene-supported diphenylamine-linked bis(oxazoline) (PS-box)-Cu(OTf)2 complex has been developed in a continuous flow system. The supported complex exhibited extremely efficient catalytic performance with high activity, affording the corresponding products in excellent yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and more than 4000 turnover number (TON).

Graphical abstract: Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

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Article information

DOI
https://doi.org/10.1039/C8OB01943F
Article type
Paper
Submitted
09 Aug 2018
Accepted
28 Sep 2018
First published
28 Sep 2018

Org. Biomol. Chem., 2018,16, 7702-7710

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Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex

B. Wang, Y. Wang, Y. Jiang, M. Chu, S. Qi, W. Ju and D. Xu, Org. Biomol. Chem., 2018, 16, 7702 DOI: 10.1039/C8OB01943F

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