Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1′-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes

Abstract

The design and synthesis of a new chiral monodentate spiro phosphoramidite ligand based on a hexamethyl-1,1′-spirobiindane scaffold has been accomplished. The ligand could serve as an elegant chiral monodentate ligand in the Pd-catalyzed asymmetric hydroamination/arylation of alkenes leading to chiral imidazolidin-2-ones with good enantioselectivities.