Eszter
Fazekas
,
Gary S.
Nichol
,
Michael P.
Shaver
and
Jennifer A.
Garden
*
EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, EH9 3FJ, UK. E-mail: j.garden@ed.ac.uk
First published on 30th August 2018
Three phenoxyimine Fe(III)Cl complexes bearing electronically diverse -Cl, -H or -tBu substituents in the ortho position were synthesised. X-ray crystallographic analysis of the complexes reveals mononuclear structures with pentacoordinate iron centres and trigonal bipyramidal geometries. All three complexes demonstrated excellent catalytic activities towards CO2/epoxide coupling to selectively form cyclic carbonates, with catalyst activity correlating with the electron withdrawing nature of the ortho-substituent (Cl > H > tBu) and thus the Lewis acidity of the metal centre. The chloro-substituted complex displayed remarkable activity in the synthesis of propylene carbonate from propylene oxide and CO2, reaching turnover frequencies (TOF) up to 760 h−1 in the presence of TBABr co-catalyst at 120 °C and 20 bars of CO2 pressure. Importantly, the catalyst is also very robust, functioning with high substrate loading, under air or in the presence of water. The substrate scope was successfully extended to other terminal epoxides including epichlorohydrin (TOF = 900 h−1) and to the more challenging internal epoxide, cyclohexene oxide (TOF = 80 h−1). These are amongst the highest TOF values reported for an iron CO2/epoxide coupling catalyst to date.
Some of the most active catalyst systems comprise homogeneous complexes with a Lewis acidic metal centre (for epoxide coordination and activation) and a nucleophile (for ring opening of the epoxide). Ligand design has enabled the development of highly efficient catalyst systems, including mono- or bi-metallic ligand supported complexes with ammonium or phosphonium salt co-catalysts, or bifunctional catalysts which incorporate the onium salt into the ligand backbone.9–12 One popular ligand framework is the privileged salen ligand scaffold, which has supported many Lewis acidic complexes mediating a wide array of small and large molecule transformations (Scheme 1).13–15 While the ubiquitous salen ligands have shown some success in CO2/epoxide coupling, their bidentate phenoxyimine (half salen) analogues have been underexplored.16 Breaking the bridge between the phenoxy groups creates a more flexible coordination environment, enabling the balance between the steric hindrance and the accessibility of the metal centre to be better fine-tuned (Scheme 1). Previous findings in the field suggest that the coordination mode of the metal centre is a key feature in allowing the efficient conversion of sterically challenging internal epoxides to cyclic carbonates.1
We have had a longstanding interest in iron-mediated catalysis thanks to its abundance, low cost, and low toxicity.17,18 In particular, Fe3+ compounds offer a user-friendly route into catalysis, due to their air- and moisture-stability which enables convenient synthesis and handling. Only a few examples of mono- or bi-metallic Fe(III) complexes have been reported as catalysts for CO2/epoxide couplings and in most cases high catalyst loadings were required to achieve good conversions.16,19–27 Uniting these joint ligand and metal benefits, we targeted a series of phenoxyimine Fe(III) chloride complexes as robust and flexible catalysts for epoxide/CO2 coupling.
The complexes proved to be oxygen- and moisture-stable, and single crystals suitable for X-ray diffraction were obtained under air. Crystals of complexes C1 and C3 were obtained via the slow evaporation of DCM, while crystals of C2 were obtained via the slow evaporation of toluene. Single crystal X-ray diffraction studies revealed that all three complexes have a mononuclear structure, with a pentacoordinate Fe(III) centre displaying a slightly distorted trigonal bipyramidal (TBP) geometry. In each case, the TBP character is high, as established using the factors of equatorial TBP (TBPe: C1 ≥ 99.9%; C2 ≥ 99.9%; C3 ≥ 99.9%) and axial TBP (TBPa: C1 ≥ 99.9%; C2 = 97.7%; C3 = 99.8%) proposed by Tamao and Ito (Fig. 1–3).29 For all three complexes, the axial N–Fe–N bond angle deviates slightly from linearity (N–Fe–N, C1, 177.44(5)°; C2, 169.7(2)°; C3, 174.92(7)°), while the sum of the equatorial O–Fe–Cl and O–Fe–O bond angles is 360° (C1, 360.00°; C2, 360.01°; C3, 360.01°). The steric bulk of the ortho-substituents notably influences the distortion of the TBP geometry at the Fe centre, with the sterically demanding tBu group leading to the greatest deviation from linearity for the N–Fe–N bond angle, and the lowest TBPa character. These ‘half salen’ frameworks significantly differ from Fe(III) salen complexes,30 as the phenoxyimine ligands are arranged such that both nitrogen and both oxygen atoms are in mutually trans positions. This difference in geometry arises from the lack of a bridge connecting the two phenoxy groups, enabling the phenoxyimine ligands to minimise the steric repulsion of the substituted imine ligands. These complexes bear similar structural motifs to those observed with related phenoxyimine Fe(III)–chloride complexes, including those with bulky substituents on the imine groups.16,31–37 The bond metrics are comparable to reported examples of structurally characterised phenoxyimine Fe(III) complexes,16 with Fe–N bond lengths ranging from 2.092(2) to 2.111(1) Å and Fe–O bond lengths ranging from 1.8757(9) to 1.889(2) Å.33,34,38
The C–O bond lengths of complexes C1, C2 and C3 are short [1.328(1) Å, 1.318(8) Å and 1.321(3) Å, respectively] in comparison to the related protonated ligand bearing a naphthalene substituent on the imine N [C–O, 1.354(2) Å].39 These short C–O bonds are indicative of resonance delocalisation of the anionic charge on the phenoxide ligand in complexes C1–C3. Furthermore, the C–C bond lengths of the (O–)CC–C(N) scaffold within C1–C3 lie between the expected bond lengths for C(aromatic)C(aromatic) double bonds and C(aromatic)–C single bonds (1.40 and 1.52 Å, respectively),40 suggestive of resonance delocalisation through the phenoxyimine moiety. This resonance delocalisation is most pronounced for the electron donating tBu-substituted complex C2 [C1–C6, 1.434(9); C6–C7, 1.43(1) Å], followed by the unsubstituted CH analogue C1 [C1–C6, 1.417(2); C6–C7, 1.447(2) Å] and the electron withdrawing Cl analogue C3 [C1–C6, 1.411(3); C6–C7, 1.450(3) Å].
To test the catalytic activity of complexes C1–C3 towards CO2/epoxide coupling, propylene oxide (PO) was selected as a benchmark substrate, as it has previously been studied with other iron catalysts.16 Initially, complex C2 was tested under solvent free conditions using 0.1 mol% catalyst loading with 0.1 mol% tetrabutylammonium iodide (TBAI) as a co-catalyst (vs. PO), using 20 bar pressure of CO2 at 120 °C. 1H and 13C NMR studies of the crude mixture revealed that the catalysts were selective towards the formation of cyclic propylene carbonate (Fig. S8†).41 Under these conditions, C2 successfully achieved 99% conversion to cyclic propylene carbonate in 12 hours (Table 1, entry 2). Control reactions testing only the Fe-complex C2 (entry 4) or only co-catalyst TBAI (entry 5) showed that both components individually display low activity, however, their combination displayed a synergistic effect with a significantly higher conversion achieved (cf. entries 1 and 3). A systematic optimisation of the reaction conditions was subsequently performed. Catalyst C2 displayed tolerance towards an increased substrate loading of 1:2000 ([Fe]:[PO]), reaching a high TOF value of 400 h−1 (Table 1, entry 6). Doubling the co-catalyst ratio from 1 to 2 equivalents (vs. catalyst C2) further improved the turnover frequency of the catalyst system, from 400 h−1 to 480 h−1 (Table 1, entries 6 and 8, respectively). Finally, tetrabutylammonium bromide (TBABr) was investigated as a co-catalyst, which resulted in a modest improvement in the catalytic activity (entry 12, TOF = 510 h−1). Kinetic studies were performed and confirmed a linear, first-order relationship between substrate conversion and time, highlighting the catalyst stability under the reaction conditions tested (Fig. 4). All three Fe(III) phenoxyimine complexes were subsequently screened for CO2/PO coupling using the optimised reaction conditions (Table 1, entries 11–13).
Fig. 4 Kinetic plot for the synthesis of propylene carbonate using C2 with 2000 equivalents of substrate. |
Entry | Complex | t (h) | [PO]/[Fe] | Co-cat. | [Co-cat]/[Fe] | Conv. (%) | TON | TOF (h−1) |
---|---|---|---|---|---|---|---|---|
Conditions: 100 ml stainless steel autoclaves, 20 bar CO2 pressure, 120 °C, neat. Conversion was determined using 1H NMR spectra of crude reaction mixtures.a The reaction was carried out without an iron complex, 2 equivalents of TBAI were added per 1000 equivalents of epoxide.b 100 equivalents H2O/[Fe] was added.c The reaction was carried out under air.d The reaction was carried out using unpurified propylene oxide (99%). | ||||||||
1 | C2 | 24 | 1000 | TBAI | 1 | 99 | 990 | 41 |
2 | C2 | 12 | 1000 | TBAI | 1 | 99 | 990 | 83 |
3 | C2 | 2 | 1000 | TBAI | 1 | 56 | 560 | 280 |
4 | C2 | 24 | 1000 | — | 0 | 13 | 130 | 5 |
5a | — | 2 | 1000 | TBAI | 2 | 15 | — | — |
6 | C2 | 2 | 2000 | TBAI | 1 | 40 | 800 | 400 |
7 | C2 | 2 | 1000 | TBAI | 2 | 91 | 910 | 455 |
8 | C2 | 2 | 2000 | TBAI | 2 | 48 | 960 | 480 |
9 | C1 | 2 | 2000 | TBAI | 2 | 48 | 960 | 480 |
10 | C3 | 2 | 2000 | TBAI | 2 | 69 | 1380 | 690 |
11 | C1 | 2 | 2000 | TBABr | 2 | 53 | 1060 | 530 |
12 | C2 | 2 | 2000 | TBABr | 2 | 51 | 1020 | 510 |
13 | C3 | 2 | 2000 | TBABr | 2 | 76 | 1520 | 760 |
14b | C3 | 2 | 2000 | TBABr | 2 | 43 | 860 | 430 |
15c | C3 | 2 | 2000 | TBABr | 2 | 65 | 1300 | 650 |
16 | C3 | 2 | 10000 | TBABr | 2 | 11 | 1100 | 550 |
17 | C3 | 26 | 10000 | TBABr | 2 | 63 | 6300 | 242 |
18d | C3 | 24 | 10000 | TBABr | 2 | 51 | 5100 | 213 |
The reactivity trends fall in line with the electron withdrawing/donating ability of the ortho-substituent, with the electron withdrawing Cl group (C3) giving the highest catalytic activity (TOF = 760 h−1, entry 13), followed by the ortho-H analogue C1 (TOF = 530 h−1, entry 11) and the electron donating tBu substituent C2 (TOF = 510 h−1, entry 12). Comparing C1–C3 to other Fe(III) catalysts known for this transformation is rather complex due to the range of different conditions used, as shown by specific catalytic comparators provided in the ESI (Table S2†). However, the high catalytic activity of ortho-chloro-substituted C3 is particularly notable, as it is amongst the fastest reported Fe-based catalyst systems for cyclic carbonate formation. It seems likely that the presence of electron withdrawing chloro- groups increases the Lewis acidity of the Fe centre, facilitating epoxide coordination to promote nucleophilic attack and ring-opening.42 These findings conform to previous studies of cobalt(III) amidoamine ligands, which showed a similar trend; complexes bearing electron withdrawing chloro- or nitro- substituents gave significantly enhanced catalyst activities in comparison to the methyl substituted analogues.43
In addition to their high catalytic activity, it is particularly noteworthy that C1, C2 and C3 are all air-stable complexes. When the coupling reaction was set up under air, ortho-chloro catalyst C3 still displayed high activities towards cyclic propylene carbonate formation, with only a minor reduction in the TOF value observed (entry 13, TOF = 760 h−1; entry 15, TOF = 650 h−1). Furthermore, catalyst system C3 also displayed some tolerance towards water; the addition of 100 equivalents of water (vs. catalyst C3) still gave high TOF values of 430 h−1 (entry 14). Catalyst C3 is noteworthy as it demonstrates high catalytic activities even at low catalyst loadings of 0.01 mol% (1:10000 [Fe]:[PO]), displaying a TOF of up to 550 h−1 after 2 hours (entry 16), slowing only after 8 hours (Fig. S12†). The robustness of C3 was further demonstrated when high conversion was maintained using 10000 equivalents of unpurified (wet) PO (entry 18). The water tolerance of catalyst C3 was supported by FT-IR spectroscopic studies (refer to ESI† for further details).
The substrate scope of catalyst C3 towards CO2/epoxide coupling was investigated by testing a range of epoxides, including cyclohexene oxide (CHO), epichlorohydrin, 1,2-epoxybutane and 1,2-epoxy-3-phenoxypropane (Table 2). Catalyst C3 demonstrated tolerance towards a broad substrate scope, successfully converting all five substrates tested to the corresponding cyclic carbonates. For the terminal epoxides, the catalyst activity falls in line with the nature of the epoxide substituent, with the presence of electron withdrawing substituents facilitating the epoxide ring opening. Accordingly, the highest conversion was observed for epichlorohydrin (TOF = 900 h−1, Table 2, entry 3), and the lowest conversion (of a terminal epoxide) was achieved for butylene oxide (TOF = 500 h−1, entry 4). In agreement with previously observed trends,1 the lowest conversions were observed for the most sterically hindered internal epoxide, cyclohexene oxide, as expected due to the formation of a strained bicyclic carbonate product. Through extending the reaction time to 48 hours, high conversion of CHO to cyclohexene carbonate (CHC) was achieved (74%, Table S1,† entry 3). This is indeed surprising, as catalysts which selectively give CHC in high yields are still rare, as many catalyst systems yield a mixture of poly(cyclohexene carbonate) (PCHC) and CHC.1,20,44,45 Importantly, catalyst C3 exclusively formed cis-CHC at high conversions, which is quite unusual as the formation of the trans-isomer often occurs through the thermodynamically favourable back-biting of a poly(cyclohexene carbonate) chain. However, resonances corresponding to trans-CHC (3.9 ppm) were absent from the 1H NMR spectra, and IR spectroscopy and mass spectrometry (EI and MALDI) studies of the product mixture confirmed the lack of polymer formation (Fig. S13–15†).1,20 The formation of cis-CHC occurs through a double inversion pathway, which can be favoured through the addition of excess co-catalyst.20,46–50
It has previously been proposed that the metal geometry is of key importance for the conversion of sterically congested internal epoxides to the corresponding cyclic carbonates, with complexes bearing a trigonal bipyramidal geometry around the metal centre typically showing greater success.1,51 Complexes C1–C3 all display a distorted trigonal bipyramidal geometry, in contrast to the square pyramidal geometries often observed with Fe(III) salen complexes.52–55 The flexible coordination modes available when using phenoxyimine ligands may present an advantage over the well-established salen analogues. These findings suggest that phenoxyimine ligand supported metal complexes have significant potential for a broad scope of CO2/epoxide coupling reactions.
Data for L2: (1.86 g, 97%) 1H NMR (500 MHz, CDCl3) δ 14.11 (s, 1H, OH), 8.35 (s, 1H, HCN), 7.31 (d, J = 7.7 Hz, 1H, ArH), 7.10 (d, J = 7.6 Hz, 1H, ArH), 6.80 (t, J = 7.6 Hz, 1H, ArH), 3.48 (d, J = 1.5 Hz, 3H, NCH3), 1.44 (s, 9H, CCH3). 13C NMR (126 MHz, CDCl3) δ 166.89 (CN), 160.51 (C-OH), 137.43, 129.32, 129.13, 118.75, 117.63 (Ar-C), 45.72 (N-CH3), 34.83 (CCH3), 29.32 (CCH3). HRMS (EI): m/z [M]+ 191.1319 calculated [M]+ 191.1310.
Data for L3: (1.10 g, 99%) 1H NMR (500 MHz, CDCl3) δ 14.51 (s, 1H, OH), 8.29 (s, 1H, HCN), 7.39 (d, J = 7.9 Hz, 1H, ArH), 7.14 (d, J = 7.7 Hz, 1H, ArH), 6.77 (t, J = 7.8 Hz, 1H, ArH), 3.49 (d, J = 1.5 Hz, 3H, CH3). 13C NMR (126 MHz, CDCl3) δ 165.8 (CN), 158.8 (C-OH), 132.7, 129.6, 122.2, 119.3, 118.1 (Ar-C) 44.9 (CH3). HRMS (EI): m/z [M]+ 169.0315 calculated [M]+ 169.0294.
Data for C1 (0.42 g, 81%) HRMS (EI): m/z [M]+ 359.0205 calculated [M]+ 359.0250 elemental analysis calculated for C16H16ClFeN2O2: C, 53.4; H, 4.5; N, 7.8. Found: C, 53.3; H, 4.65; N, 7.6.
Data for C2 (2.11 g, 98%) HRMS (EI): m/z [M]+ 471.1523 calculated [M]+ 471.1502 elemental analysis calculated for C24H32FeN2O2: C, 61.1; H, 6.84; N, 5.9. Found: C, 60.2; H, 6.2; N, 6.0.
Data for C3 (0.49 g, 74%) HRMS (EI): m/z [M]+ 426.9474 calculated [M]+ 426.9475 elemental analysis calculated for C16H14Cl3FeN2O2: C, 44.85; H, 3.3; N, 6.5. Found: C, 44.7; H, 3.35; N, 6.5.
Footnote |
† Electronic supplementary information (ESI) available: 1H and 13C NMR spectra and single crystal X-ray diffraction data. CCDC 1855808–1855810. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8dt02919a |
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