Issue 20, 2018

Peptide supramolecular materials for therapeutics

Abstract

Supramolecular assembly of peptide-based monomers into nanostructures offers many promising applications in advanced therapies. In this Tutorial Review, we introduce molecular designs to control the structure and potential biological function of supramolecular assemblies. An emphasis is placed on peptide-based supramolecular nanostructures that are intentionally designed to signal cells, either directly through the incorporation of amino acid sequences that activate receptors or indirectly by recruiting native signals such as growth factors. Additionally, we describe the use and future potential of hierarchical structures, such as single molecules that assemble into nanoscale fibers which then align to form macroscopic strings; the strings can then serve as scaffolds for cell growth, proliferation, and differentiation.

Graphical abstract: Peptide supramolecular materials for therapeutics

Article information

Article type
Tutorial Review
Submitted
23 Oct 2017
First published
06 Sep 2018

Chem. Soc. Rev., 2018,47, 7539-7551

Author version available

Peptide supramolecular materials for therapeutics

K. Sato, M. P. Hendricks, L. C. Palmer and S. I. Stupp, Chem. Soc. Rev., 2018, 47, 7539 DOI: 10.1039/C7CS00735C

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