Issue 6, 2019
From the journal:

Chemical Communications

Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding†

Shunsuke Okada,‡a   Motonori Matsusaki, ORCID logo ‡b   Kenta Arai,c   Yuji Hidaka,d   Kenji Inaba, ORCID logo e   Masaki Okumura ORCID logo *be  and  Takahiro Muraoka ORCID logo *af  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
E-mail: muraoka@go.tuat.ac.jp

b Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3 Aramaki-Aza-Aoba, Aoba-ku, Sendai 980-8578, Japan
E-mail: okmasaki@mail.tagen.tohoku.ac.jp

c Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292, Japan

d Graduate School of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan

e Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan

f Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Japan

Abstract

Coupling of thiol and urea-type –NHC([double bond, length as m-dash]X)NH2 (X = O or NH) groups is effective in promoting oxidative protein folding. In particular, a thiol compound coupled with a guanidyl (X = NH) group significantly accelerates the rates of folding processes and enhances the yields of native proteins.

Graphical abstract: Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

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Article information

DOI
https://doi.org/10.1039/C8CC08657E
Article type
Communication
Submitted
30 Oct 2018
Accepted
26 Nov 2018
First published
27 Nov 2018

Chem. Commun., 2019,55, 759-762

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Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

S. Okada, M. Matsusaki, K. Arai, Y. Hidaka, K. Inaba, M. Okumura and T. Muraoka, Chem. Commun., 2019, 55, 759 DOI: 10.1039/C8CC08657E

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